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Gene

vegfaa

ID
ZDB-GENE-990415-273
Name
vascular endothelial growth factor Aa
Symbol
vegfaa Nomenclature History
Previous Names
  • vegf-a (1)
  • vegf (1)
  • vegfa (1)
  • etID309976.16 (1)
  • wu:fj82c06
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Enables growth factor activity. Acts upstream of or within several processes, including animal organ development; circulatory system development; and regulation of vasculature development. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; podocyte; and trunk. Used to study proteinuria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
97 figures from 77 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
45 figures from 25 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vegfaa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Microvascular complications of diabetes 1} 603933
Associated With vegfaa Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023581 Platelet-derived growth factor, conserved site
Domain IPR000072 PDGF/VEGF domain
Domain IPR027928 Vascular endothelial growth factor, heparin-binding domain
Homologous_superfamily IPR029034 Cystine-knot cytokine
Homologous_superfamily IPR036841 Vascular endothelial growth factor, heparin-binding domain superfamily
Domain Details Per Protein
Protein Length Cystine-knot cytokine PDGF/VEGF domain Platelet-derived growth factor, conserved site Vascular endothelial growth factor, heparin-binding domain Vascular endothelial growth factor, heparin-binding domain superfamily
UniProtKB:O73682 188
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-vegfaa polyclonal IgG Goat
  • WB
R&D Systems
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations