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ZFIN ID: ZDB-FIG-061226-29
Montero-Balaguer et al., 2006 - The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists   235(12):3199-3212 Full text @ Dev. Dyn.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Term:
Stage: 26+ somites

Fig. 4 Pigment cell progenitors show deficits in the mosm188 mutants. Expression analysis of pigment specific genes in wild type (A, C, E, G) lateral and (A', C', E', G') dorsal views, and in mosm188 mutants (B, D, F, H) lateral and (B', D', F', H') dorsal views as revealed by whole mount in situ hybridization in 22 hpf embryos. A-B': Expression of mitfa/nac, the early marker of pigment progenitors, is significantly downregulated in the trunk region while the mid-hindbrain boundary domain is unaffected in mosm188 mutants. C-D': Similarly, the melanophores specific dct/trp2 expression is largely absent in mosm188 mutants at this stage. E-F':Fms that specifies melanophore and xanthophore lineages is essentially absent in mosm188mutants as is xanthine dehydrogenase (G-H';), the enzyme in pteridine synthesis pathway that marks lineage-committed xanthoblasts.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
aox5 WT standard conditions 26+ somites pigment cell ISH
foxd3m188(AB) standard conditions 26+ somites Not Detected pigment cell ISH
csf1ra WT standard conditions 26+ somites pigment cell ISH
foxd3m188(AB) standard conditions 26+ somites Not Detected pigment cell ISH
dct WT standard conditions 26+ somites pigment cell ISH
foxd3m188(AB) standard conditions 26+ somites Not Detected pigment cell ISH
mitfa WT standard conditions 26+ somites pigment cell ISH
foxd3m188(AB) standard conditions 26+ somites pigment cell ISH
Antibody Labeling Details No data available
Phenotype Details No data available
Acknowledgments:
ZFIN wishes to thank the journal Developmental dynamics : an official publication of the American Association of Anatomists for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dev. Dyn.