Gene

aox5

ID
ZDB-GENE-001205-2
Name
aldehyde oxidase 5
Symbol
aox5 Nomenclature History
Previous Names
  • aox2 (1)
  • aox3 (1)
  • aoxa (1)
  • aox alpha (1)
  • etID47878.22 (1)
  • fc18g02
  • wu:fc18g02
  • xdh
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have flavin adenine dinucleotide binding activity and xanthine dehydrogenase activity. Predicted to be involved in xanthine catabolic process. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Is expressed in several structures, including fin; neural crest; pigment cell; post-vent region; and xanthoblast. Orthologous to human AOX1 (aldehyde oxidase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
35 figures from 21 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With aox5 Human Ortholog
No data available
Associated With aox5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
Domain IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
Domain IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
Domain IPR002346 Molybdopterin dehydrogenase, FAD-binding
Domain IPR002888 [2Fe-2S]-binding
Domain IPR005107 CO dehydrogenase flavoprotein, C-terminal
Domain IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
Domain IPR014307 Xanthine dehydrogenase, small subunit
Domain IPR016166 FAD-binding domain, PCMH-type
Family IPR016208 Aldehyde oxidase/xanthine dehydrogenase
Homologous_superfamily IPR012675 Beta-grasp domain superfamily
Homologous_superfamily IPR016167 FAD-binding, type PCMH, subdomain 1
Homologous_superfamily IPR016169 FAD-binding, type PCMH, subdomain 2
Homologous_superfamily IPR036010 2Fe-2S ferredoxin-like superfamily
Homologous_superfamily IPR036318 FAD-binding, type PCMH-like superfamily
Homologous_superfamily IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamily
Homologous_superfamily IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
Homologous_superfamily IPR036884 [2Fe-2S]-binding domain superfamily
Homologous_superfamily IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
Domain Details Per Protein
Protein Length [2Fe-2S]-binding [2Fe-2S]-binding domain superfamily 2Fe-2S ferredoxin, iron-sulphur binding site 2Fe-2S ferredoxin-like superfamily 2Fe-2S ferredoxin-type iron-sulfur binding domain Aldehyde oxidase/xanthine dehydrogenase Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily Beta-grasp domain superfamily CO dehydrogenase flavoprotein, C-terminal CO dehydrogenase flavoprotein, C-terminal domain superfamily FAD-binding domain, PCMH-type FAD-binding, type PCMH-like superfamily FAD-binding, type PCMH, subdomain 1 FAD-binding, type PCMH, subdomain 2 Molybdopterin dehydrogenase, FAD-binding Xanthine dehydrogenase, small subunit
UniProtKB:M1ZMM0 1336
UniProtKB:Q1LW04 1241
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations