ZFIN ID: ZDB-GENE-001205-1
Gene Name: colony stimulating factor 1 receptor, a
Gene Symbol: csf1ra    Nomenclature History

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Previous Names: c-fms (1), csf1r, fms (1), pfe (1), sal (1), salz (1), panther, pfeffer (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have growth factor binding activity and macrophage colony-stimulating factor receptor activity. Involved in several processes, including immune response in brain or nervous system; macrophage chemotaxis; and myeloid leukocyte differentiation. Predicted to localize to CSF1-CSF1R complex; integral component of plasma membrane; and receptor complex. Is expressed in several structures, including hematopoietic cell; neural crest cell; osteoclast; pigment cell; and rostral blood island. Used to study CSF1R-related brain malformation and osteopetrosis. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor).
Genome Resources: Alliance (1),  Gene:64274 (1),  Ensembl(GRCz11):ENSDARG00000102986 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
csf1ra_unspecified Unspecified Unknown Unknown
j4blue Small Deletion Unknown Frameshift, Premature Stop
j4e1 Point Mutation Unknown Missense ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • j4e2 Point Mutation Unknown Missense ENU
    mh5 Unknown Unknown Unknown ENU
    sa9484 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15067 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22726 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tb213c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tc227b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • te220 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tf34 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tf238b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tg17 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tg283a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tl241 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm236b Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm246b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp71c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tq211 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tt254a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • utr4e174A Point Mutation Unknown Missense ENU
    utr4e536 Unknown Unknown Unknown ENU
    utr4e564 Unknown Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-csf1ra N/A 2
    DISEASE ASSOCIATED WITH csf1ra HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    adult-onset leukoencephalopathy with axonal spheroids and pigmented glia Alliance Leukoencephalopathy, diffuse hereditary, with spheroids 221820
    Brain abnormalities, neurodegeneration, and dysosteosclerosis 618476
    DISEASE ASSOCIATED WITH csf1ra VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    CSF1R-related brain malformation and osteopetrosis csf1raj4e1/j4e1 standard conditions Oosterhof et al., 2019
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process developmental pigmentation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 40)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA csf1ra-201 (1)    Ensembl 3459
    ncRNA csf1ra-002 (1)    Ensembl 2788
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-csf1ra polyclonal IgG Rabbit WB AnaSpec
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM csf1ra
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(csf1ra-e1b:gfp) csf1raE1B GFP Danio rerio 1 1
    TgBAC(csf1ra:GAL4-VP16) csf1ra GAL4VP16 Danio rerio 1 28
    TgBAC(csf1ra:GFP) csf1ra GFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    csf1ra Contained in: [Fosmid] CH1073-425O22 (1), ZFOS-1069F5 (1)
    csf1ra Encodes: [cDNA] cssl:d116 (1), MGC:194643 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131672 (1) 3581 nt
    Genomic GenBank:FP102999 (1) 40159 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q9U7 (1) 977 aa
    Sequence Information (all 28)
    ORTHOLOGY for csf1ra ( Chr: 14 )
    CITATIONS (181)