FIGURE

Fig. 6

ID

ZDB-FIG-060322-6

Publication

Seiliez et al., 2006 - FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation

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Fig. 6

Inhibition of Wnt8a signaling rescues the headless phenotype of gsc/foxA3 knock-down embryos. Expression of the telencephalic marker emx1 in wild-type embryo (A), in double gsc/foxa3 knock-down embryo (B), in gsc/foxa3 knock-down embryo coinjected with either frzb RNA (C), dkk1 RNA (D) or wnt8a Mo (E). (F–J) Morphological analysis of embryos treated with the same conditions of injections than in panels A–E showing rescue of the head at 32 hpf when the Wnt signaling pathway is inhibited. (K) Frequency of the phenotypic classes observed for the abovementioned injections. (A–E) 2–3 somite stage, dorsal views; (F–J) lateral views at 32 hpf.

Expression Data

Gene:	emx1
Fish:	WT WT + MO1-foxa3 + MO1-gsc WT + MO1-foxa3 + MO1-gsc + MO1-wnt8a
Knockdown Reagents:	MO1-foxa3 MO1-gsc MO1-wnt8a
Anatomical Term:	presumptive telencephalon
Stage:	1-4 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-foxa3 + MO1-gsc WT + MO1-foxa3 + MO1-gsc + MO1-wnt8a
Knockdown Reagents:	MO1-foxa3 MO1-gsc MO1-wnt8a
Observed In:	eye head head morphogenesis
Stage Range:	Prim-5 to Prim-15

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 290(1), Seiliez, I., Thisse, B., and Thisse, C., FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation, 152-163, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.