FIGURE SUMMARY
Title

Di-2-ethylhexyl phthalate induces heart looping disorders during zebrafish development

Authors
Sun, Y., Yang, F., Liu, Y., Yu, M., Wu, F., Wang, G.
Source
Full text @ Toxicol. Ind. Health
Fig. 1

DEHP-induced mortality in zebrafish larva. At 1 dpf, no significant difference was found in embryonic lethality between control and DEHP groups. At 2 and 3 dpf, zebrafish mortality was significantly increased in the DEHP group. *p < 0.05 and **p < 0.01. DEHP: di-2-ethylhexyl phthalate; dpf: day postfertilization.

Fig. 2

Heart rate changes induced by DEHP injection. The average heart rate of zebrafish larvae was significantly decreased in the DEHP group at 3 and 4 dpf. **p < 0.01. DEHP: di-2-ethylhexyl phthalate; dpf: day postfertilization.

Fig. 3

DEHP injection induced pericardial edema and heart looping disorder in zebrafish. (a) Representative image of massive pericardial edema in DEHP-treated zebrafish at 3 dpf. (b) The incidence of pericardial edema in DEHP-treated zebrafish larvae. **p < 0.01. (c) Representative image of heart looping disorder in DEHP-treated zebrafish larvae. A: atrium; V: ventricle. (d) The average AV distance in DEHP-treated zebrafish larvae. **p < 0.01. DEHP: di-2-ethylhexyl phthalate; dpf: day postfertilization; AV: atrial-ventricular.

Fig. 4

Detection of heart development transcription factors in DEHP-treated zebrafish larvae. *p < 0.05 and **p < 0.01. DEHP: di-2-ethylhexyl phthalate.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Toxicol. Ind. Health
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