Gene

zic3

ID

ZDB-GENE-030708-2

Name

zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)

Symbol

zic3 Nomenclature History

Previous Names

cb807 (1)
id:ibd2176
wu:fj52a10
wu:fq33c12

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior axis specification and determination of left/right symmetry. Predicted to localize to nucleus. Used to study right atrial isomerism; spina bifida; and visceral heterotaxy. Human ortholog(s) of this gene implicated in X-linked VACTERL association; situs inversus; and visceral heterotaxy. Is expressed in several structures, including central nervous system; mesoderm; neural keel; neural plate; and presumptive structure. Orthologous to human ZIC3 (Zic family member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb807 (25 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zic3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
visceral heterotaxy	Alliance	Congenital heart defects, nonsyndromic, 1, X-linked	306955
visceral heterotaxy	Alliance	Heterotaxy, visceral, 1, X-linked	306955
X-linked VACTERL association	Alliance	VACTERL association, X-linked	314390

Associated With zic3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
right atrial isomerism	TU + MO4-zic3	standard conditions	Li et al., 2018
spina bifida	AB + MO1-zic3	standard conditions	Cast et al., 2012
visceral heterotaxy	AB + MO1-zic3	standard conditions	Cast et al., 2012

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Domain	IPR041643	ZIC protein, zinc finger domain
Family	IPR050329	GLI C2H2-type zinc-finger
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily