ZFIN

ZFIN ID: ZDB-TGCONSTRCT-110210-2

ZFIN ID: ZDB-TGCONSTRCT-110210-2

CITATIONS (55 total)

Transgenic Construct Name:	Tg(cryaa:DsRed,-5.1myl7:Cre-ERT2)
Transgenic Construct Symbol:	Tg(cryaa:DsRed,-5.1myl7:Cre-ERT2)

Rouf, M.A., Kürekçi, G.K., Zhang, S., Vanier, S.L., Kamel, S.M., Lee, A.N., Yang, R.B., Lai, S.L., Marín-Juez, R. (2026) Developmental single-cell atlas of coronary growth and cardiomyocyte interaction in zebrafish. Development (Cambridge, England). :

Bouwman, M., de Bakker, D.E.M., Honkoop, H., Giovou, A.E., Versteeg, D., Boender, A.R., Nguyen, P.D., Slotboom, M., Colquhoun, D., Vigil-Garcia, M., Kooijman, L., Janssen, R., Hooijkaas, I.B., Günthel, M., Visser, K.J., Klerk, M., Zentilin, L., Giacca, M., Kaslin, J., Boink, G.J.J., van Rooij, E., Christoffels, V.M., Bakkers, J. (2025) Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration. Nature cardiovascular research. 4(1):64-82

Pronobis, M.I., DeLuca, S., Lee, S., Garcia, L., Ou, J., Bursac, N., Poss, K.D. (2025) Ddx61-enriched condensates refine heart regeneration programs. Nature communications. 16:89928992

Rao, A., Russell, A., Segura-Bermudez, J., Franz, C., Dockery, R., Blatnik, A., Panten, J., Zevallos, M., McNulty, C., Pietrzak, M., Goldman, J.A. (2025) A cardiac transcriptional enhancer is repurposed during regeneration to activate an anti-proliferative program. Development (Cambridge, England). :

She, P., Gao, B., Li, D., Wu, C., Zhu, X., He, Y., Mo, F., Qi, Y., Jin, D., Chen, Y., Zhao, X., Lin, J., Hu, H., Li, J., Zhang, B., Xie, P., Lin, C., Christoffels, V.M., Wu, Y., Zhu, P., Zhong, T.P. (2025) The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis. Nature communications. 16:232232

Varanasi, S.M., Sabharwal, A., Mukherjee, S., Muhammad, H., Kar, R., Magnano, C., Dorairaj, A., Wang, E., Dutta, S., Das, P., Ekker, S.C., Wang, Y., Mukhopadhyay, D., Angom, R.S. (2025) Vascular Endothelial Growth Factor B Modulates Cardiac Functions via Ferroptosis Pathways in Post-Myocardial Infarction. Cells. 14:

Duca, S., Xia, Y., Elmagid, L.A., Bakis, I., Qiu, M., Cao, Y., Guo, Y., Eichenbaum, J.V., McCain, M.L., Kang, J., Harrison, M.R.M., Cao, J. (2024) Differential vegfc expression dictates lymphatic response during zebrafish heart development and regeneration. Development (Cambridge, England). 151(22):

Gauvrit, S., Zhao, S., Rothbauer, U., Stainier, D.Y.R. (2024) A β-catenin chromobody-based probe highlights endothelial maturation during vascular morphogenesis in vivo. Development (Cambridge, England). 151(11):

Sam, J., Torregroza, I., Evans, T. (2024) Gata6 functions in zebrafish endoderm to regulate late differentiating arterial pole cardiogenesis. Development (Cambridge, England). 151(17):

Shin, K., Rodriguez-Parks, A., Kim, C., Silaban, I.M., Xia, Y., Sun, J., Dong, C., Keles, S., Wang, J., Cao, J., Kang, J. (2024) Harnessing the regenerative potential of interleukin11 to enhance heart repair. Nature communications. 15:96669666

Nguyen, P.D., Gooijers, I., Campostrini, G., Verkerk, A.O., Honkoop, H., Bouwman, M., de Bakker, D.E.M., Koopmans, T., Vink, A., Lamers, G.E.M., Shakked, A., Mars, J., Mulder, A.A., Chocron, S., Bartscherer, K., Tzahor, E., Mummery, C.L., de Boer, T.P., Bellin, M., Bakkers, J. (2023) Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration. Science (New York, N.Y.). 380:758764758-764

Rao, A., Lyu, B., Jahan, I., Lubertozzi, A., Zhou, G., Tedeschi, F., Jankowsky, E., Kang, J., Carstens, B., Poss, K.D., Baskin, K., Goldman, J.A. (2023) The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regeneration. Development (Cambridge, England). 150(20):

Sun, F., Ou, J., Shoffner, A.R., Luan, Y., Yang, H., Song, L., Safi, A., Cao, J., Yue, F., Crawford, G.E., Poss, K.D. (2022) Enhancer selection dictates gene expression responses in remote organs during tissue regeneration. Nature cell biology. 24(5):685-696

Ogawa, M., Geng, F.S., Humphreys, D.T., Kristianto, E., Sheng, D.Z., Hui, S.P., Zhang, Y., Sugimoto, K., Nakayama, M., Zheng, D., Hesselson, D., Hodson, M.P., Bogdanovic, O., Kikuchi, K. (2021) Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish. Science (New York, N.Y.). 372:201-205

Pronobis, M.I., Zheng, S., Singh, S.P., Goldman, J.A., Poss, K.D. (2021) In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration. eLIFE. 10:

Wang, Y., Lu, X., Wang, X., Qiu, Q., Zhu, P., Ma, L., Ma, X., Herrmann, J., Lin, X., Wang, W., Xu, X. (2021) atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity. Circulation research. 129(8):e166-e182

Apaydin, D.C., Jaramillo, P.A.M., Corradi, L., Cosco, F., Rathjen, F.G., Kammertoens, T., Filosa, A., Sawamiphak, S. (2020) Early-Life Stress Regulates Cardiac Development through an IL-4-Glucocorticoid Signaling Balance. Cell Reports. 33:108404

Beisaw, A., Kuenne, C., Günther, S., Dallmann, J., Wu, C.C., Bentsen, M., Looso, M., Stainier, D. (2020) AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion during Zebrafish Heart Regeneration. Circulation research. 126(12):1760-1778

Bertozzi, A., Wu, C.C., Nguyen, P.D., Vasudevarao, M.D., Mulaw, M.A., Koopman, C.D., de Boer, T.P., Bakkers, J., Weidinger, G. (2020) Is zebrafish heart regeneration "complete"? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts. Developmental Biology. 471:106-118

Ding, Y., Yang, J., Chen, P., Lu, T., Jiao, K., Tester, D.J., Giudicessi, J.R., Jiang, K., Ackerman, M.J., Li, Y., Wang, D.W., Lee, H.C., Wang, D.W., Xu, X. (2020) Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy. Journal of the American Heart Association. 9(17):e017055

Fukuda, R., Marín-Juez, R., El-Sammak, H., Beisaw, A., Ramadass, R., Kuenne, C., Guenther, S., Konzer, A., Bhagwat, A.M., Graumann, J., Stainier, D.Y. (2020) Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO reports. 21(8):e49752

Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A.V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S.C., Hsiai, T.K., Lin, X., Xu, X. (2020) Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. Science advances. 6:eaay2939

She, P., Zhang, H., Peng, X., Sun, J., Gao, B., Zhou, Y., Zhu, X., Hu, X., Lai, K.S., Wong, J., Zhou, B., Wang, L., Zhong, T.P. (2020) The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase. Development (Cambridge, England). 147(18):

Shoffner, A., Cigliola, V., Lee, N., Ou, J., Poss, K.D. (2020) Tp53 Suppression Promotes Cardiomyocyte Proliferation during Zebrafish Heart Regeneration. Cell Reports. 32:108089

Ben-Yair, R., Butty, V.L., Busby, M., Qiu, Y., Levine, S.S., Goren, A., Boyer, L.A., Burns, C.G., Burns, C.E. (2019) H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration. Development (Cambridge, England). 146(19):

Gálvez-Santisteban, M., Chen, D., Zhang, R., Serrano, R., Nguyen, C., Zhao, L., Nerb, L., Masutani, E.M., Vermot, J., Burns, C.G., Burns, C.E., Del Álamo, J.C., Chi, N.C. (2019) Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming. eLIFE. 8:

Han, Y., Chen, A., Umansky, K.B., Oonk, K.A., Choi, W.Y., Dickson, A.L., Ou, J., Cigliola, V., Yifa, O., Cao, J., Tornini, V.A., Cox, B.D., Tzahor, E., Poss, K.D. (2019) Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish. Developmental Cell. 48(6):853-863.e5

Honkoop, H., de Bakker, D.E., Aharonov, A., Kruse, F., Shakked, A., Nguyen, P.D., de Heus, C., Garric, L., Muraro, M.J., Shoffner, A., Tessadori, F., Peterson, J.C., Noort, W., Bertozzi, A., Weidinger, G., Posthuma, G., Grun, D., van der Laarse, W.J., Klumperman, J., Jaspers, R.T., Poss, K.D., van Oudenaarden, A., Tzahor, E., Bakkers, J. (2019) Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. eLIFE. 8:

Marín-Juez, R., El-Sammak, H., Helker, C.S.M., Kamezaki, A., Mullapuli, S.T., Bibli, S.I., Foglia, M.J., Fleming, I., Poss, K.D., Stainier, D.Y.R. (2019) Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. Developmental Cell. 51:503-515.e4

González-Rosa, J.M., Sharpe, M., Field, D., Soonpaa, M.H., Field, L.J., Burns, C.E., Burns, C.G. (2018) Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish. Developmental Cell. 44:433-446.e7

Karra, R., Foglia, M.J., Choi, W.Y., Belliveau, C., DeBenedittis, P., Poss, K.D. (2018) Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 115(35):8805-8810

Goldman, J.A., Kuzu, G., Lee, N., Karasik, J., Gemberling, M., Foglia, M.J., Karra, R., Dickson, A.L., Sun, F., Tolstorukov, M.Y., Poss, K.D. (2017) Resolving Heart Regeneration by Replacement Histone Profiling. Developmental Cell. 40:392-404.e5

Sawamiphak, S., Kontarakis, Z., Filosa, A., Reischauer, S., Stainier, D.Y.R. (2017) Transient cardiomyocyte fusion regulates cardiac development in zebrafish. Nature communications. 8:1525

Cao, J., Navis, A., Cox, B.D., Dickson, A.L., Gemberling, M., Karra, R., Bagnat, M., Poss, K.D. (2016) Single epicardial cell transcriptome sequencing identifies Caveolin-1 as an essential factor in zebrafish heart regeneration. Development (Cambridge, England). 143(2):232-43

Foglia, M.J., Cao, J., Tornini, V.A., Poss, K.D. (2016) Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium. Development (Cambridge, England). 143(10):1688-96

Han, P., Bloomekatz, J., Ren, J., Zhang, R., Grinstein, J.D., Zhao, L., Burns, C.G., Burns, C.E., Anderson, R.M., Chi, N.C. (2016) Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature. 534:700-4

Kang, J., Hu, J., Karra, R., Dickson, A.L., Tornini, V.A., Nachtrab, G., Gemberling, M., Goldman, J.A., Black, B.L., Poss, K.D. (2016) Modulation of tissue repair by regeneration enhancer elements. Nature. 532(7598):201-6

Gemberling, M., Karra, R., Dickson, A.L., Poss, K.D. (2015) Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. eLIFE. 4

Harrison, M.R., Bussmann, J., Huang, Y., Zhao, L., Osorio, A., Burns, C.G., Burns, C.E., Sucov, H.M., Siekmann, A.F., Lien, C.L. (2015) Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Developmental Cell. 33:442-54

Karra, R., Knecht, A.K., Kikuchi, K., Poss, K.D. (2015) Myocardial NF-κB activation is essential for zebrafish heart regeneration. Proceedings of the National Academy of Sciences of the United States of America. 112(43):13255-60

Schindler, Y.L., Garske, K.M., Wang, J., Firulli, B.A., Firulli, A.B., Poss, K.D., Yelon, D. (2014) Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. Development (Cambridge, England). 141(16):3112-22

Choi, W.Y., Gemberling, M., Wang, J., Holdway, J.E., Shen, M.C., Karlstrom, R.O., and Poss, K.D. (2013) In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development (Cambridge, England). 140(3):660-666

Fang, Y., Gupta, V., Karra, R., Holdway, J.E., Kikuchi, K., and Poss, K.D. (2013) Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Proceedings of the National Academy of Sciences of the United States of America. 110(33):13416-13421

Gupta, V., Gemberling, M., Karra, R., Rosenfeld, G.E., Evans, T., and Poss, K.D. (2013) An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle. Current biology : CB. 23(13):1221-7

Pan, Y.A., Freundlich, T., Weissman, T.A., Schoppik, D., Wang, X.C., Zimmerman, S., Ciruna, B., Sanes, J.R., Lichtman, J.W., and Schier, A.F. (2013) Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish. Development (Cambridge, England). 140(13):2835

Gupta, V., and Poss, K.D. (2012) Clonally dominant cardiomyocytes direct heart morphogenesis. Nature. 484(7395):479-484

Manuel González-Rosa, J., Peralta, M., and Mercader, N. (2012) Pan-epicardial lineage tracing reveals that epicardium derived cells give rise to myofibroblasts and perivascular cells during zebrafish heart regeneration. Developmental Biology. 370(2):173-186

Kikuchi, K., Gupta, V., Wang, J., Holdway, J.E., Wills, A.A., Fang, Y., and Poss, K.D. (2011) tcf21⁺ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development (Cambridge, England). 138(14):2895-902

Wang, J., Panáková, D., Kikuchi, K., Holdway, J.E., Gemberling, M., Burris, J.S., Singh, S.P., Dickson, A.L., Lin, Y.F., Sabeh, M.K., Werdich, A.A., Yelon, D., MacRae, C.A., and Poss, K.D. (2011) The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development (Cambridge, England). 138(16):3421-30

Kikuchi, K., Holdway, J.E., Werdich, A.A., Anderson, R.M., Fang, Y., Egnaczyk, G.F., Evans, T., MacRae, C.A., Stainier, D.Y., and Poss, K.D. (2010) Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature. 464(7288):601-605

Liu, J., Bressan, M., Hassel, D., Huisken, J., Staudt, D., Kikuchi, K., Poss, K.D., Mikawa, T., and Stainier, D.Y. (2010) A dual role for ErbB2 signaling in cardiac trabeculation. Development (Cambridge, England). 137(22):3867-3875

Additional Citations (4):

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

ZIRC and ZFIN staff (2013) Mutant and Transgenic Line Submissions 2013. ZFIN Direct Data Submission.

ZIRC and ZFIN Staff (2008) Mutant and Transgenic Line Submissions 2008. ZFIN Direct Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.