ZFIN

ZFIN ID: ZDB-GENE-100727-2

ZFIN ID: ZDB-GENE-100727-2

CITATIONS (58 total)

Gene Name:	interleukin 13
Gene Symbol:	il13

Guo, D., Xiong, H., Yang, Z., Zhang, R., Shi, P., Yao, Y., Liu, M., Xu, C., Wang, Q.K. (2024) Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e23870e23870

Huang, Y., Chen, Y., Xie, H., Feng, Y., Chen, S., Bao, B. (2024) Effects of Inducible Nitric Oxide Synthase (iNOS) Gene Knockout on the Diversity, Composition, and Function of Gut Microbiota in Adult Zebrafish. Biology. 13(6):

Lu, C., Hyde, D.R. (2024) Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina. Frontiers in cell and developmental biology. 12:14063301406330

Sobah, M.L., Liongue, C., Ward, A.C. (2024) Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities. Journal of Innate Immunity. 16(1):262-282

Arthi, B., Chellathai, D. (2023) Effects of vasicine in neuroinflammatory zebrafish model. Bioinformation. 19:595604595-604

Palsamy, K., Chen, J.Y., Skaggs, K., Qadeer, Y., Connors, M., Cutler, N., Richmond, J., Kommidi, V., Poles, A., Affrunti, D., Powell, C., Goldman, D., Parent, J.M. (2023) Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling. Glia. 71(11):2642-2663

Cafora, M., Poerio, N., Forti, F., Loberto, N., Pin, D., Bassi, R., Aureli, M., Briani, F., Pistocchi, A., Fraziano, M. (2022) Evaluation of phages and liposomes as combination therapy to counteract Pseudomonas aeruginosa infection in wild-type and CFTR-null models. Frontiers in microbiology. 13:979610

Chen, K., Wang, P., Chen, J., Ying, Y., Chen, Y., Gilson, E., Lu, Y., Ye, J. (2022) Loss of atm in Zebrafish as a Model of Ataxia-Telangiectasia Syndrome. Biomedicines. 10(2):

Morales, R.A., Rabahi, S., Diaz, O.E., Salloum, Y., Kern, B.C., Westling, M., Luo, X., Parigi, S.M., Monasterio, G., Das, S., Hernández, P.P., Villablanca, E.J. (2022) Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal immunology. 15(5):940-951

Shao, T., Ji, J.F., Zheng, J.Y., Li, C., Zhu, L.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 208(12):2686-2701

Wen, W., Chen, J., Zhou, Y., Li, G., Zhang, Y. (2022) Loss of Ripk3 attenuated neutrophil accumulation in a lipopolysaccharide-induced zebrafish inflammatory model. Cell death discovery. 8:88

Cronan, M.R., Hughes, E.J., Brewer, W.J., Viswanathan, G., Hunt, E.G., Singh, B., Mehra, S., Oehlers, S.H., Gregory, S.G., Kaushal, D., Tobin, D.M. (2021) A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. Cell. 184(7):1757-1774.e14

Cui, X., Du, C., Wan, S., Wu, D., Yan, L., Zhang, J., Li, J., Li, H., Yang, Z., Zhang, H., Zhang, J., Mu, H., Zhang, F., Peng, X., Liu, M., Hu, Y. (2021) Deficiency of Heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21^cip1 expression. Biochimica et biophysica acta. Molecular basis of disease. 1867(11):166233

Farr, D.A., Nag, D., Withey, J.H. (2021) Characterization of the Immune Response to Vibrio cholerae Infection in a Natural Host Model. Frontiers in cellular and infection microbiology. 11:722520

Lai, C.Y., Yeh, K.Y., Liu, B.F., Chang, T.M., Chang, C.H., Liao, Y.F., Liu, Y.W., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish. Cancers. 13(21):

Bottiglione, F., Dee, C.T., Lea, R., Zeef, L.A.H., Badrock, A.P., Wane, M., Bugeon, L., Dallman, M.J., Allen, J.E., Hurlstone, A.F.L. (2020) Zebrafish IL-4-like Cytokines and IL-10 Suppress Inflammation but Only IL-10 Is Essential for Gill Homeostasis. Journal of immunology (Baltimore, Md. : 1950). 205(4):994-1008

Chang, C.C., Lu, Y.C., Wang, C.C., Ko, T.L., Chen, J.R., Wang, W., Chen, Y.L., Wang, Y.W., Chang, T.H., Hsu, H.F., Houng, J.Y. (2020) Antrodia cinnamomea Extraction Waste Supplementation Promotes Thermal Stress Tolerance and Tissue Regeneration Ability of Zebrafish. Molecules. 25(18):

Diaz, O.E., Xue, S., Luo, X., Nava, J., Appelblom, A., Morales, R.A., Das, S., Villablanca, E.J. (2020) Retinoic acid induced cytokines are selectively modulated by Liver X Receptor activation in zebrafish. Reproductive toxicology (Elmsford, N.Y.). 93:163-168

Bollaerts, I., Van Houcke, J., Beckers, A., Lemmens, K., Vanhunsel, S., De Groef, L., Moons, L. (2019) Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish. Mediators of inflammation. 2019:6135795

Giallongo, C., Tibullo, D., Camiolo, G., Parrinello, N.L., Romano, A., Puglisi, F., Barbato, A., Conticello, C., Lupo, G., Anfuso, C.D., Lazzarino, G., Li Volti, G., Palumbo, G.A., Di Raimono, F. (2019) TLR4 signaling drives mesenchymal stromal cells commitment to promote tumor microenvironment transformation in multiple myeloma. Cell Death & Disease. 10:704

Qiao, R., Deng, Y., Zhang, S., Wolosker, M.B., Zhu, Q., Ren, H., Zhang, Y. (2019) Accumulation of different shapes of microplastics initiates intestinal injury and gut microbiota dysbiosis in the gut of zebrafish. Chemosphere. 236:124334

Ayaz Ahmed, K.B., Raman, T., Veerappan, A. (2018) Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish. Scientific Reports. 8:2200

Hernández, P.P., Strzelecka, P.M., Athanasiadis, E.I., Hall, D., Robalo, A.F., Collins, C.M., Boudinot, P., Levraud, J.P., Cvejic, A. (2018) Single-cell transcriptional analysis reveals ILC-like cells in zebrafish. Science immunology. 3(29):

Jensen, H.M., Korbut, R., Kania, P.W., Buchmann, K. (2018) Cannabidiol effects on behaviour and immune gene expression in zebrafish (Danio rerio). PLoS One. 13:e0200016

Jørgensen, L.V.G., Korbut, R., Jeberg, S., Kania, P.W., Buchmann, K. (2018) Association between adaptive immunity and neutrophil dynamics in zebrafish (Danio rerio) infected by a parasitic ciliate. PLoS One. 13:e0203297

Myllymäki, H., Niskanen, M., Luukinen, H., Parikka, M., Rämet, M. (2018) Identification of protective postexposure mycobacterial vaccine antigens using an immunosuppression-based reactivation model in the zebrafish. Disease models & mechanisms. 11(3)

Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11

Shao, T., Shi, W., Zheng, J.Y., Xu, X.X., Lin, A.F., Xiang, L.X., Shao, J.Z. (2018) Costimulatory Function of Cd58/Cd2 Interaction in Adaptive Humoral Immunity in a Zebrafish Model. Frontiers in immunology. 9:1204

Van Gennip, J.L.M., Boswell, C.W., Ciruna, B. (2018) Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis. Science advances. 4:eaav1781

Al-Samadi, A., Awad, S.A., Tuomainen, K., Zhao, Y., Salem, A., Parikka, M., Salo, T. (2017) Crosstalk between tongue carcinoma cells, extracellular vesicles, and immune cells in in vitro and in vivo models.. Oncotarget. 8:60123-60134

Haarder, S., Kania, P.W., Holm, T.L., von Gersdorff Jørgensen, L., Buchmann, K. (2017) Effect of ES-products from Anisakis (Nematoda: Anisakidae) on experimentally induced colitis in adult zebrafish. Parasite immunology. 39(10)

Mehrdana, F., Kania, P.W., Nazemi, S., Buchmann, K. (2017) Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model. PLoS One. 12:e0181277

Tokunaga, Y., Shirouzu, M., Sugahara, R., Yoshiura, Y., Kiryu, I., Ototake, M., Nagasawa, T., Somamoto, T., Nakao, M. (2017) Comprehensive validation of T- and B-cell deficiency in rag1-null zebrafish: Implication for the robust innate defense mechanisms of teleosts. Scientific Reports. 7:7536

Wu, S.Y., Wang, L.D., Xu, G.M., Yang, S.D., Deng, Q.F., Li, Y.Y., Huang, R. (2017) spv locus aggravates Salmonella infection of zebrafish adult by inducing Th1/Th2 shift to Th2 polarization. Fish & shellfish immunology. 67:684-691

Dee, C.T., Nagaraju, R.T., Athanasiadis, E.I., Gray, C., Fernandez Del Ama, L., Johnston, S.A., Secombes, C.J., Cvejic, A., Hurlstone, A.F. (2016) CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes. Journal of immunology (Baltimore, Md. : 1950). 197(9):3520-3530

Liu, C., Su, G., Giesy, J.P., Letcher, R.J., Li, G., Agrawal, I., Li, J., Yu, L., Wang, J., Gong, Z. (2016) Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish. Scientific Reports. 6:19045

Wang, T., Johansson, P., Abós, B., Holt, A., Tafalla, C., Jiang, Y., Wang, A., Xu, Q., Qi, Z., Huang, W., Costa, M.M., Diaz-Rosales, P., Holland, J.W., Secombes, C.J. (2016) First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities. Oncotarget. 7(10):10917-46

Yang, C., Li, Z., Kang, W., Tian, Y., Yan, Y., Chen, W. (2016) TET1 and TET3 are essential in induction of Th2-type immunity partly through regulation of IL-4/13A expression in zebrafish model. Gene. 591(1):201-8

Yang, Z.J., Li, C.H., Chen, J., Zhang, H., Li, M.Y., Chen, J. (2016) Molecular characterization of an interleukin-4/13B homolog in grass carp (Ctenopharyngodon idella) and its role in fish against Aeromonas hydrophila infection. Fish & shellfish immunology. 57:136-47

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Liu, X., Wu, H., Liu, Q., Wang, Q., Xiao, J., Chang, X., Zhang, Y. (2015) Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish & shellfish immunology. 45(2):342-5

Yoon, S., Mitra, S., Wyse, C., Alnabulsi, A., Zou, J., Weerdenburg, E.M., van der Sar, A.M., Wang, D., Secombes, C.J., Bird, S. (2015) First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio). PLoS One. 10:e0126378

Hammarén, M.M., Oksanen, K.E., Nisula, H.M., Luukinen, B.V., Pesu, M., Rämet, M., Parikka, M. (2014) Adequate Th2-Type Response Associates with Restricted Bacterial Growth in Latent Mycobacterial Infection of Zebrafish. PLoS pathogens. 10:e1004190

Zhang, H., Shen, B., Wu, H., Gao, L., Liu, Q., Wang, Q., Xiao, J., Zhang, Y. (2014) Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes. Fish & shellfish immunology. 37:229-38

Zhu, L.Y., Pan, P.P., Fang, W., Shao, J.Z., and Xiang, L.X. (2012) Essential Role of IL-4 and IL-4Ralpha Interaction in Adaptive Immunity of Zebrafish: Insight into the Origin of Th2-like Regulatory Mechanism in Ancient Vertebrates. Journal of immunology (Baltimore, Md. : 1950). 188(11):5571-5584

Pan, C.Y., Wu, J.L., Hui, C.F., Lin, C.H., and Chen, J.Y. (2011) Insights into the antibacterial and immunomodulatory functions of the antimicrobial peptide, epinecidin-1, against Vibrio vulnificus infection in zebrafish. Fish & shellfish immunology. 31(6):1019-25

Gong, Y.F., Xiang, L.X., and Shao, J.Z. (2009) CD154-CD40 interactions are essential for thymus-dependent antibody production in zebrafish: insights into the origin of costimulatory pathway in helper T cell-regulated adaptive immunity in early vertebrates. Journal of immunology (Baltimore, Md. : 1950). 182(12):7749-7762

Ohtani, M., Hayashi, N., Hashimoto, K., Nakanishi, T., and Dijkstra, J.M. (2008) Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish. Immunogenetics. 60(7):383-397

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (9):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Varshney, G.K., Zhang, S., Burgess, S.M., ZFIN Staff (2015) Automated Data Load From CRISPRz. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.