PUBLICATION
Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish
- Authors
- Ayaz Ahmed, K.B., Raman, T., Veerappan, A.
- ID
- ZDB-PUB-180206-4
- Date
- 2018
- Source
- Scientific Reports 8: 2200 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Adaptive Immunity
- Adjuvants, Immunologic/metabolism*
- Aeromonas hydrophila/immunology*
- Animals
- Disease Models, Animal
- Gram-Negative Bacterial Infections/prevention & control*
- Nanoparticles/metabolism*
- Plant Lectins/metabolism*
- Platinum/metabolism*
- Survival Analysis
- Zebrafish
- PubMed
- 29396408 Full text @ Sci. Rep.
Citation
Ayaz Ahmed, K.B., Raman, T., Veerappan, A. (2018) Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish. Scientific Reports. 8:2200.
Abstract
Bacterial resistance is a major clinical problem, which is compounded by both a lack of new antibiotics and emergence of multi- and extremely-drug resistant microbes. In this context, non-toxic nanoparticles could play an important role in conferring protection against bacterial infections and in this study we have made an attempt to show the usefulness of jacalin capped platinum nanoparticles in protecting zebrafish against multiple infections with Aeromonas hydrophila. Our results also indicate that use of nanoparticles promotes adaptive immune response against the pathogen, so much so that zebrafish is able to survive repetitive infection even after twenty one days of being treated with jacalin-capped platinum nanoparticles. This is significant given that platinum salt is not antibacterial and jacalin is non-immunogenic. Our study for the first time reveals a novel mechanism of action of nanoparticles, which could form an alternate antibacterial strategy with minimal bacterial resistance.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping