ZFIN

ZFIN ID: ZDB-GENE-080514-1

ZFIN ID: ZDB-GENE-080514-1

CITATIONS (70 total)

Gene Name:	solute carrier family 18 member 2
Gene Symbol:	slc18a2

Bao, Y., Du, Y., Zhang, J., Li, M., Man, X., Gu, K., Li, J., Feng, X. (2025) Paternal periconceptional exposure to reserpine and antidepressants causes developmental abnormalities and ADHD-like behavior in offspring: A deep learning analysis. Journal of psychiatric research. 191:226237226-237

Barnes, M., Burton, D., Marsden, K., Kullman, S.W. (2025) Early disruptions in vitamin D receptor signaling induces persistent developmental behavior deficits in zebrafish larvae. PLoS One. 20:e0335156e0335156

Hanot, M., Völkel, P., Le Bourhis, X., Lagadec, C., Angrand, P.O. (2025) Ezh2 Loss-of-Function Alters Zebrafish Cerebellum Development. International Journal of Molecular Sciences. 26:

Tagkalidou, N., Stevanović, M., Romero-Alfano, I., Elizalde-Velázquez, G.A., Herrera-Vázquez, S.E., Prats, E., Gómez-Canela, C., Gómez-Oliván, L.M., Raldúa, D. (2025) Motor and Non-Motor Effects of Acute MPTP in Adult Zebrafish: Insights into Parkinson's Disease. International Journal of Molecular Sciences. 26:

Correia, D., Bellot, M., Goyenechea, J., Prats, E., Moro, H., Gómez-Canela, C., Bedrossiantz, J., Tagkalidou, N., Ferreira, C.S.S., Raldúa, D., Domingues, I., Faria, M., Oliveira, M. (2024) Parental exposure to antidepressants has lasting effects on offspring? A case study with zebrafish. Chemosphere. 355:141851

Tea, M., Pan, Y.K., Lister, J.G.R., Perry, S.F., Gilmour, K.M. (2024) Effects of serta and sertb knockout on aggression in zebrafish (Danio rerio). Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 210(5):785-799

Altbürger, C., Holzhauser, J., Driever, W. (2023) CRISPR/Cas9-based QF2 knock-in at the tyrosine hydroxylase (th) locus reveals novel th-expressing neuron populations in the zebrafish mid- and hindbrain. Frontiers in Neuroanatomy. 17:11968681196868

Altbürger, C., Rath, M., Wehrle, J., Driever, W. (2023) The proneural factors Ascl1a and Ascl1b contribute to the terminal differentiation of dopaminergic GABAergic dual transmitter neurons in zebrafish. Developmental Biology. 505:587458-74

Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273

Khalili, A., Safarian, N., van Wijngaarden, E., Zoidl, G.S., Zoidl, G.R., Rezai, P. (2023) Loss of Panx1 function in zebrafish alters motor behavior in a lab-on-chip model of Parkinson's disease. Journal of neuroscience research. 101(12):1814-1825

Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300

Gabellini, C., Pucci, C., De Cesari, C., Martini, D., Di Lauro, C., Digregorio, M., Norton, W., Zippo, A., Sessa, A., Broccoli, V., Andreazzoli, M. (2022) CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish. International Journal of Molecular Sciences. 24(1):

Pan, W., Godoy, R.S., Cook, D.P., Scott, A.L., Nurse, C.A., Jonz, M.G. (2022) Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Scientific Reports. 12:10144

Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417

Sveinsdóttir, H.S., Decker, A., Christensen, C., Lucena, P.B., Þorsteinsson, H., Richert, E., Maier, V.H., Cornell, R., Karlsson, K.Æ. (2022) Motility phenotype in a zebrafish vmat2 mutant. PLoS One. 17:e0259753

Zhou, J., Peng, C., Li, Q., Yan, X., Yang, L., Li, M., Cao, X., Xie, X., Chen, D., Rao, C., Huang, S., Peng, F., Pan, X. (2022) Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells. Frontiers in pharmacology. 13:837810

Baronio, D., Chen, Y.C., Decker, A.R., Enckell, L., Fernández-López, B., Semenova, S., Puttonen, H.A.J., Cornell, R.A., Panula, P. (2021) Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish. Acta physiologica (Oxford, England). 234(1):e13725

Baronio, D., Chen, Y.C., Panula, P. (2021) Abnormal brain development of monoamine oxidase mutant zebrafish and impaired social interaction of heterozygous fish. Disease models & mechanisms. 15(3):

Faria, M., Prats, E., Bellot, M., Gomez-Canela, C., Raldúa, D. (2021) Pharmacological Modulation of Serotonin Levels in Zebrafish Larvae: Lessons for Identifying Environmental Neurotoxicants Targeting the Serotonergic System. Toxics. 9(6):

Faria, M., Prats, E., Rosas Ramírez, J.R., Bellot, M., Bedrossiantz, J., Pagano, M., Valls, A., Gomez-Canela, C., Porta, J.M., Mestres, J., Garcia-Reyero, N., Faggio, C., Gómez Oliván, L.M., Raldua, D. (2021) Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion. The Science of the total environment. 775:145671

Kumar, N., Zhao, H.N., Awoyemi, O., Kolodziej, E.P., Crago, J. (2021) Toxicity Testing of Effluent-Dominated Stream Using Predictive Molecular-Level Toxicity Signatures Based on High-Resolution Mass Spectrometry: A Case Study of the Lubbock Canyon Lake System. Environmental science & technology. 55(5):3070-3080

Li, Z., Cao, P., Meng, H., Li, D., Zhang, Y., Li, Y., Wang, S. (2021) Long-term exposure to 2-amino-3-methylimidazo[4,5-f]quinoline can trigger a potential risk of Parkinson's disease. Journal of hazardous materials. 412:125230

Cao, Z., Su, M., Wang, H., Zhou, L., Meng, Z., Xiong, G., Liao, X., Lu, H. (2020) Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae. Chemosphere. 270:128611

Faria, M., Bedrossiantz, J., Ramírez, J.R.R., Mayol, M., García, G.H., Bellot, M., Prats, E., Garcia-Reyero, N., Gómez-Canela, C., Gómez-Oliván, L.M., Raldúa, D. (2020) Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety. Environment International. 146:106253

Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171

Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538

Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525

Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942

Bruning, J.M., Wang, Y., Oltrabella, F., Tian, B., Kholodar, S.A., Liu, H., Bhattacharya, P., Guo, S., Holton, J.M., Fletterick, R.J., Jacobson, M.P., England, P.M. (2019) Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell chemical biology. 26(5):674-685.e6

Tang, Y.Q., Li, Z.R., Zhang, S.Z., Mi, P., Chen, D.Y., Feng, X.Z. (2019) Venlafaxine plus melatonin ameliorate reserpine-induced depression-like behavior in zebrafish. Neurotoxicology and teratology. 76:106835

Naderi, M., Salahinejad, A., Ferrari, M.C.O., Niyogi, S., Chivers, D.P. (2018) Dopaminergic dysregulation and impaired associative learning behavior in zebrafish during chronic dietary exposure to selenium. Environmental pollution (Barking, Essex : 1987). 237:174-185

Tanaka, Y., Fujiwara, M., Shindo, A., Yin, G., Kitazawa, T., Teraoka, H. (2018) Aroclor 1254 and BDE-47 inhibit dopaminergic function manifesting as changes in locomotion behaviors in zebrafish embryos. Chemosphere. 193:1207-1215

Zhang, X., Jia, S., Chen, Z., Chong, Y.L., Xie, H., Feng, D., Wu, X., Song, D.Z., Roy, S., Zhao, C. (2018) Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 50(12):1666-1673

Allalou, A., Wu, Y., Ghannad-Rezaie, M., Eimon, P.M., Yanik, M.F. (2017) Automated deep-phenotyping of the vertebrate brain. eLIFE. 6

Cunha, V., Rodrigues, P., Santos, M.M., Moradas-Ferreira, P., Ferreira, M. (2017) Fluoxetine modulates the transcription of genes involved in serotonin, dopamine and adrenergic signalling in zebrafish embryos. Chemosphere. 191:954-961

Puttonen, H.A.J., Semenova, S., Sundvik, M., Panula, P. (2017) Storage of neural histamine and histaminergic neurotransmission is VMAT2 dependent in the zebrafish. Scientific Reports. 7:3060

Puttonen, H.A.J., Sundvik, M., Semenova, S., Shirai, Y., Chen, Y.C., Panula, P. (2017) Knock-out of histamine receptor H3 alters adaptation to sudden darkness and monoamine levels in the zebrafish. Acta physiologica (Oxford, England). 222(3)

Xie, Y., Kaufmann, D., Moulton, M.J., Panahi, S., Gaynes, J.A., Watters, H.N., Zhou, D., Xue, H.H., Fung, C.M., Levine, E.M., Letsou, A., Brennan, K.C., Dorsky, R.I. (2017) Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biology. 15:e2002257

Chen, Y.C., Semenova, S., Rozov, S., Sundvik, M., Bonkowsky, J.L., Panula, P. (2016) A novel developmental role for dopaminergic signaling to specify hypothalamic neurotransmitter identity. The Journal of biological chemistry. 291(42):21880-21892

Du, Y., Guo, Q., Shan, M., Wu, Y., Huang, S., Zhao, H., Hong, H., Yang, M., Yang, X., Ren, L., Peng, J., Sun, J., Zhou, H., Li, S., Su, B. (2016) Spatial and Temporal Distribution of Dopaminergic Neurons during Development in Zebrafish. Frontiers in Neuroanatomy. 10:115

Wang, Y., Li, S., Liu, W., Wang, F., Hu, L.F., Zhong, Z.M., Wang, H., Liu, C.F. (2016) Vesicular Monoamine Transporter 2 (Vmat2)knockdown elicits anxiety-like behavior in zebrafish. Biochemical and Biophysical Research Communications. 470(4):792-7

Huang, J., Zhong, Z., Wang, M., Chen, X., Tan, Y., Zhang, S., He, W., He, X., Huang, G., Lu, H., Wu, P., Che, Y., Yan, Y.L., Postlethwait, J.H., Chen, W., Wang, H. (2015) Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:2572-87

Ren, G., Li, S., Zhong, H., and Lin, S. (2013) Zebrafish tyrosine hydroxylase 2 Gene Encodes Tryptophan Hydroxylase. The Journal of biological chemistry. 288(31):22451-9

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Fujimoto, E., Stevenson, T.J., Chien, C.B., and Bonkowsky, J.L. (2011) Identification of a Dopaminergic Enhancer Indicates Complexity in Vertebrate Dopamine Neuron Phenotype Specification. Developmental Biology. 352(2):393-404

Yamamoto, K., Ruuskanen, J.O., Wullimann, M.F., and Vernier, P. (2011) Differential expression of dopaminergic cell markers in the adult zebrafish forebrain. The Journal of comparative neurology. 519(3):576-598

Jacobsson, J.A., Stephansson, O., and Fredriksson, R. (2010) C6ORF192 Forms a Unique Evolutionary Branch Among Solute Carriers (SLC16, SLC17, and SLC18) and Is Abundantly Expressed in Several Brain Regions. Journal of molecular neuroscience : MN. 41(2):230-242

Yamamoto, K., Ruuskanen, J.O., Wullimann, M.F., and Vernier, P. (2010) Two tyrosine hydroxylase genes in vertebrates: New dopaminergic territories revealed in the zebrafish brain. Molecular and cellular neurosciences. 43(4):394-402

Wen, L., Wei, W., Gu, W., Huang, P., Ren, X., Zhang, Z., Zhu, Z., Lin, S., and Zhang, B. (2008) Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish. Developmental Biology. 314(1):84-92

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Additional Citations (20):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Manual Curation of UniProt IDs. Manually curated data.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

Zebrafish Nomenclature Committee (2021) Nomenclature Data Curation (2021). Nomenclature Committee Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.