Gene

slc18a2

ID

ZDB-GENE-080514-1

Name

solute carrier family 18 member 2

Symbol

slc18a2 Nomenclature History

Previous Names

vmat2 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable serotonin:sodium:chloride symporter activity. Acts upstream of or within several processes, including startle response; swimming behavior; and thigmotaxis. Predicted to be located in membrane. Predicted to be active in synaptic vesicle membrane and terminal bouton. Is expressed in brain and neurons. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in Parkinson's disease; infantile parkinsonism-dystonia 2; and type 1 diabetes mellitus. Orthologous to human SLC18A2 (solute carrier family 18 member A2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 11 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc18a2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
infantile parkinsonism-dystonia 2	Alliance	Parkinsonism-dystonia, infantile, 2	618049

Associated With slc18a2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
anxiety disorder	slc18a2^sus100/+	standard conditions	Wang et al., 2016
anxiety disorder	slc18a2^sus101/+	standard conditions	Wang et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR020846	Major facilitator superfamily domain
Family	IPR004734	Multidrug resistance protein
Family	IPR011701	Major facilitator superfamily
Family	IPR050930	Major Facilitator Superfamily Vesicular Transporter
Homologous_superfamily	IPR036259	MFS transporter superfamily