ZFIN is now using GRCz12tu for Genomic Data
Gene
slc18a2
- ID
- ZDB-GENE-080514-1
- Name
- solute carrier family 18 member 2
- Symbol
- slc18a2 Nomenclature History
- Previous Names
-
- vmat2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable serotonin:sodium:chloride symporter activity. Acts upstream of or within several processes, including startle response; swimming behavior; and thigmotaxis. Predicted to be located in membrane. Predicted to be active in synaptic vesicle membrane and terminal bouton. Is expressed in brain; female organism; male organism; and neurons. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in Parkinson's disease and infantile parkinsonism-dystonia 2. Orthologous to human SLC18A2 (solute carrier family 18 member A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| infantile parkinsonism-dystonia 2 | Alliance | Parkinsonism-dystonia, infantile, 2 | 618049 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| anxiety disorder | slc18a2sus100/+ | standard conditions | Wang et al., 2016 |
| anxiety disorder | slc18a2sus101/+ | standard conditions | Wang et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR020846 | Major facilitator superfamily domain |
| Family | IPR001958 | Tetracycline resistance protein TetA/multidrug resistance protein MdtG-like |
| Family | IPR011701 | Major facilitator superfamily |
| Family | IPR050930 | Major Facilitator Superfamily Vesicular Transporter |
| Homologous_superfamily | IPR036259 | MFS transporter superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Major facilitator superfamily | Major facilitator superfamily domain | Major Facilitator Superfamily Vesicular Transporter | MFS transporter superfamily | Tetracycline resistance protein TetA/multidrug resistance protein MdtG-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q5CZP4 | InterPro | 562 | |||||
| UniProtKB:A0A8M1P3E9 | InterPro | 515 | |||||
| UniProtKB:A0AC58HN18 | InterPro | 353 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc18a2-201
(1)
|
Ensembl | 1,762 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers