ZFIN

ZFIN ID: ZDB-GENE-070508-4

ZFIN ID: ZDB-GENE-070508-4

CITATIONS (76 total)

Gene Name:	glucose-6-phosphate dehydrogenase
Gene Symbol:	g6pd

Noble, A.R., Masek, M., Hofmann, C., Cuoco, A., Rusterholz, T.D.S., Özkoc, H., Greter, N.R., Phelps, I.G., Vladimirov, N., Kollmorgen, S., Stoeckli, E., Bachmann-Gagescu, R. (2024) Shared and unique consequences of Joubert Syndrome gene dysfunction on the zebrafish central nervous system. Biology Open. 13(11):

Tan, V.W.T., Salmi, T.M., Karamalakis, A.P., Gillespie, A., Ong, A.J.S., Balic, J.J., Chan, Y.C., Bladen, C.E., Brown, K.K., Dawson, M.A., Cox, A.G. (2024) SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway. Developmental Cell. 59(7):898-910.e6

Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201

Choi, S.S.A., Chan, H.H., Chan, C.M., Wang, X., Webb, S.E., Leung, K.W., Tsim, K.W.K., Miller, A.L. (2022) Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry. Journal of virology. 96(24):e0141822

Facchinello, N., Astone, M., Audano, M., Oberkersch, R.E., Spizzotin, M., Calura, E., Marques, M., Crisan, M., Mitro, N., Santoro, M.M. (2022) Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Nature metabolism. 4:123-140

Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509

Masek, M., Etard, C., Hofmann, C., Hülsmeier, A.J., Zang, J., Takamiya, M., Gesemann, M., Neuhauss, S.C.F., Hornemann, T., Strähle, U., Bachmann-Gagescu, R. (2022) Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition. Nature communications. 13:1282

Pagán, A.J., Lee, L.J., Edwards-Hicks, J., Moens, C.B., Tobin, D.M., Busch-Nentwich, E.M., Pearce, E.L., Ramakrishnan, L. (2022) mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity. Cell. 185(20):3720-3738.e13

Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595

Wang, X., Lin, S., Tang, R.W., Lee, H.C., Chan, H.H., Choi, S.S.A., Leung, K.W., Webb, S.E., Miller, A.L., Tsim, K.W. (2022) Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae. Phytomedicine : international journal of phytotherapy and phytopharmacology. 102:154154

Wohlfart, D.P., Lou, B., Middel, C.S., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Hell, R., Hammes, H.P., Szendrödi, J., Nawroth, P.P., Kroll, J. (2022) Accumulation of acetaldehyde in aldh2.1^-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. Redox Biology. 50:102249

Zhou, W., Wang, Y., Wang, J., Peng, C., Wang, Z., Qin, H., Li, G., Li, D. (2022) β-Ionone causes endocrine disruption, hyperpigmentation and hypoactivity in zebrafish early life stages. The Science of the total environment. 834:155433

Ding, Y., Li, Y., Zhao, Z., Cliff Zhang, Q., Liu, F. (2021) The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling. eLIFE. 10:

Hotz, A.L., Jamali, A., Rieser, N.N., Niklaus, S., Aydin, E., Myren-Svelstad, S., Lalla, L., Jurisch-Yaksi, N., Yaksi, E., Neuhauss, S.C.F. (2021) Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia. 70(1):196-214

Keller, R.M., Beaver, L.M., Reardon, P.N., Prater, M.C., Truong, L., Robinson, M.M., Tanguay, R.L., Stevens, J.F., Hord, N.G. (2021) Nitrate-induced improvements in exercise performance are coincident with exuberant changes in metabolic genes and the metabolome in zebrafish skeletal muscle. Journal of applied physiology (Bethesda, Md. : 1985). 131(1):142-157

Sinclair, J.W., Hoying, D.R., Bresciani, E., Nogare, D.D., Needle, C.D., Berger, A., Wu, W., Bishop, K., Elkahloun, A.G., Chitnis, A., Liu, P., Burgess, S.M. (2021) The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration. NPJ Regenerative medicine. 6:55

Arogbokun, O., Shevik, M., Slusher, T., Farouk, Z., Elfstrum, A., Weber, J., Cusick, S.E., Lund, T. (2020) Traditional African remedies induce hemolysis in a glucose-6-phopshate dehydrogenase deficient zebrafish model. Scientific Reports. 10:19172

Kwok, M.L., Hu, X.L., Meng, Q., Chan, K.M. (2020) Whole-transcriptome sequencing (RNA-seq) analyses of the zebrafish liver cell line, ZFL, after acute exposure to Cu²⁺ ions. Metallomics : integrated biometal science. 12(5):732-751

Kwok, M.L., Meng, Q., Hu, X.L., Chung, C.T., Chan, K.M. (2020) Whole-transcriptome sequencing (RNA-seq) study of the ZFL zebrafish liver cell line after acute exposure to Cd²⁺ ions. Aquatic toxicology (Amsterdam, Netherlands). 228:105628

Luciani, A., Schumann, A., Berquez, M., Chen, Z., Nieri, D., Failli, M., Debaix, H., Festa, B.P., Tokonami, N., Raimondi, A., Cremonesi, A., Carrella, D., Forny, P., Kölker, S., Diomedi Camassei, F., Diaz, F., Moraes, C.T., Di Bernardo, D., Baumgartner, M.R., Devuyst, O. (2020) Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency. Nature communications. 11:970

Martínez-Navarro, F.J., Martínez-Morcillo, F.J., López-Muñoz, A., Pardo-Sánchez, I., Martínez-Menchón, T., Corbalán-Vélez, R., Cayuela, M.L., Pérez-Oliva, A.B., García-Moreno, D., Mulero, V. (2020) The vitamin B6-dependent enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation. Developmental and comparative immunology. 108:103666

Fu, J., Tan, Y.X.R., Gong, Z., Bae, S. (2019) The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos. Ecotoxicology and environmental safety. 189:110039

Lu, D.L., Ma, Q., Wang, J., Li, L.Y., Han, S.L., Limbu, S.M., Li, D.L., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2019) Fasting enhances cold resistance in fish through stimulating lipid catabolism and autophagy. The Journal of physiology. 597(6):1585-1603

Park, K.H., Kim, S.H. (2019) Low dose of chronic ethanol exposure in adult zebrafish induces hepatic steatosis and injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 117:109179

Richardson, R., Owen, N., Toms, M., Young, R.M., Tracey-White, D., Moosajee, M. (2019) Transcriptome profiling of zebrafish optic fissure fusion. Scientific Reports. 9:1541

Zhao, C., Wang, M., Jia, Z., Li, E., Zhao, X., Li, F., Lin, R. (2019) Similar hepatotoxicity response induced by Rhizoma Paridis in zebrafish larvae, cell and rat. Journal of ethnopharmacology. 250:112440

Alfonso, S., Blanc, M., Joassard, L., Keiter, S.H., Munschy, C., Loizeau, V., Bégout, M.L., Cousin, X. (2018) Examining multi- and transgenerational behavioral and molecular alterations resulting from parental exposure to an environmental PCB and PBDE mixture. Aquatic toxicology (Amsterdam, Netherlands). 208:29-38

Hwang, S., Mruk, K., Rahighi, S., Raub, A.G., Chen, C.H., Dorn, L.E., Horikoshi, N., Wakatsuki, S., Chen, J.K., Mochly-Rosen, D. (2018) Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Nature communications. 9:4045

Pan, Y.X., Luo, Z., Zhuo, M.Q., Wei, C.C., Chen, G.H., Song, Y.F. (2018) Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Aquatic toxicology (Amsterdam, Netherlands). 199:12-20

Pan, Y.X., Zhuo, M.Q., Li, D.D., Xu, Y.H., Wu, K., Luo, Z. (2018) SREBP-1 and LXRα pathways mediated Cu-induced hepatic lipid metabolism in zebrafish Danio rerio. Chemosphere. 215:370-379

Sopezki, M.D.S., Monserrat, J.M., Yunes, J.S., Zanette, J. (2018) Validation of Housekeeping Genes as Internal Controls for the Study of the Effects of Microcystin-LR in Zebrafish by Real-Time PCR. Zebrafish. 15(5):454-459

Torvund-Jensen, J., Steengaard, J., Askebjerg, L.B., Kjaer-Sorensen, K., Laursen, L.S. (2018) The 3'UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish. Frontiers in molecular neuroscience. 11:185

Wu, Y.H., Lee, Y.H., Shih, H.Y., Chen, S.H., Cheng, Y.C., Tsun-Yee Chiu, D. (2018) Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis. Cell Death & Disease. 9:10

Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613

Bonnet, A., Lambert, G., Ernest, S., Dutrieux, F.X., Coulpier, F., Lemoine, S., Lobbardi, R., Rosa, F.M. (2017) Quaking RNA-Binding Proteins Control Early Myofibril Formation by Modulating Tropomyosin. Developmental Cell. 42(5):527-541.e4

Holowiecki, A., O'Shields, B., Jenny, M.J. (2017) Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 191:138-151

Sarty, K.I., Cowie, A., Martyniuk, C.J. (2017) The legacy pesticide dieldrin acts as a teratogen and alters the expression of dopamine transporter and dopamine receptor 2a in zebrafish (Danio rerio) embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 194:37-47

Yang, Y.J., Wang, Y., Li, Z., Zhou, L., Gui, J.F. (2017) Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish.. Genetics. 205(4):1551-1572

Guh, Y.J., Yang, C.Y., Liu, S.T., Huang, C.J., Hwang, P.P. (2016) Oestrogen-related receptor α is required for transepithelial H+ secretion in zebrafish. Proceedings. Biological sciences. 283(1825):20152582

Houbrechts, A.M., Delarue, J., Gabriëls, I.J., Sourbron, J., Darras, V.M. (2016) Permanent Deiodinase Type 2 Deficiency Strongly Perturbs Zebrafish Development, Growth, and Fertility. Endocrinology. 157:3668-81

Moriyama, Y., Ito, F., Takeda, H., Yano, T., Okabe, M., Kuraku, S., Keeley, F.W., Koshiba-Takeuchi, K. (2016) Evolution of the fish heart by sub/neofunctionalization of an elastin gene. Nature communications. 7:1039710397

Perrichon, P., Le Menach, K., Akcha, F., Cachot, J., Budzinski, H., Bustamante, P. (2016) Toxicity assessment of water-accommodated fractions from two different oils using a zebrafish (Danio rerio) embryo-larval bioassay with a multilevel approach. The Science of the total environment. 568:952-66

Bhumika, S., Lemmens, K., Vancamp, P., Moons, L., Darras, V.M. (2015) Decreased thyroid hormone signaling accelerates the reinnervation of the optic tectum following optic nerve crush in adult zebrafish. Molecular and cellular neurosciences. 68:92-102

Bui-Nguyen, T.M., Baer, C.E., Lewis, J.A., Yang, D., Lein, P.J., Jackson, D.A. (2015) Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio. BMC Genomics. 16:853

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Rocha, F., Dias, J., Engrola, S., Gavaia, P., Geurden, I., Dinis, M.T., Panserat, S. (2015) Glucose metabolism and gene expression in juvenile zebrafish (Danio rerio) challenged with a high carbohydrate diet: effects of an acute glucose stimulus during late embryonic life. The British journal of nutrition. 113(3):403-13

Tian, J., He, G., Mai, K., Liu, C. (2015) Effects of postprandial starvation on mRNA expression of endocrine-, amino acid and peptide transporter-, and metabolic enzyme-related genes in zebrafish (Danio rerio). Fish physiology and biochemistry. 41(3):773-87

Wlodarchak, N., Tariq, R., Striker, R. (2015) Comparative analysis of the human and zebrafish kinomes: focus on the development of kinase inhibitors. Trends in cell & molecular biology. 10:49-75

Larcher, T., Perrichon, P., Vignet, C., Ledevin, M., Le Menach, K., Lyphout, L., Landi, L., Clerandeau, C., Lebihanic, F., Ménard, D., Burgeot, T., Budzinski, H., Akcha, F., Cachot, J., Cousin, X. (2014) Chronic dietary exposure of zebrafish to PAH mixtures results in carcinogenic but not genotoxic effects. Environmental science and pollution research international. 21(24):13833-49

Rocha, F., Dias, J., Engrola, S., Gavaia, P., Geurden, I., Dinis, M.T., and Panserat, S. (2014) Glucose overload in yolk has little effects on the long term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). The Journal of experimental biology. 217(Pt 7):1139-49

Harris, J.M., Esain, V., Frechette, G.M., Harris, L.J., Cox, A.G., Cortes, M., Garnaas, M.K., Carroll, K.J., Cutting, C.C., Khan, T., Elks, P.M., Renshaw, S.A., Dickinson, B.C., Chang, C.J., Murphy, M.P., Paw, B.H., Vander Heiden, M.G., Goessling, W., and North, T.E. (2013) Glucose metabolism impacts the spatio-temporal onset and magnitude of HSC induction in vivo. Blood. 121(13):2483-2493

Patrinostro, X., Carter, M.L., Kramer, A.C., and Lund, T.C. (2013) A Model of Glucose-6-Phosphate Dehydrogenase Deficiency in the Zebrafish. Experimental hematology. 41(8):697-710.e2

Seiliez, I., Médale, F., Aguirre, P., Larquier, M., Lanneretonne, L., Alami-Durante, H., Panserat, S., and Skiba-Cassy, S. (2013) Postprandial regulation of growth- and metabolism-related factors in zebrafish. Zebrafish. 10(2):237-248

Zheng, J.L., Luo, Z., Zhu, Q.L., Tan, X.Y., Chen, Q.L., Sun, L.D., and Hu, W. (2013) Molecular cloning and expression pattern of 11 genes involved in lipid metabolism in yellow catfish Pelteobagrus fulvidraco. Gene. 531(1):53-63

Kolmakov, N.N., Kube, M., Reinhardt, R., and Canario, A.V. (2008) Analysis of the goldfish Carassius auratus olfactory epithelium transcriptome reveals the presence of numerous non-olfactory GPCR and putative receptors for progestin pheromones. BMC Genomics. 9:429

McCurley, A.T., and Callard, G.V. (2008) Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment. BMC Molecular Biology. 9:102

Additional Citations (20):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2012) Gene Ontology annotation based on UniPathway vocabulary mapping. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.