PUBLICATION
β-Ionone causes endocrine disruption, hyperpigmentation and hypoactivity in zebrafish early life stages
- Authors
- Zhou, W., Wang, Y., Wang, J., Peng, C., Wang, Z., Qin, H., Li, G., Li, D.
- ID
- ZDB-PUB-220426-3
- Date
- 2022
- Source
- The Science of the total environment 834: 155433 (Journal)
- Registered Authors
- Keywords
- Locomotion, Melanin, Taste and odor, Toxicity
- MeSH Terms
-
- Animals
- Ecosystem
- Embryo, Nonmammalian
- Hyperpigmentation*
- Larva
- Norisoprenoids
- Water Pollutants, Chemical*/metabolism
- Zebrafish/physiology
- PubMed
- 35461947 Full text @ Sci. Total Environ.
Citation
Zhou, W., Wang, Y., Wang, J., Peng, C., Wang, Z., Qin, H., Li, G., Li, D. (2022) β-Ionone causes endocrine disruption, hyperpigmentation and hypoactivity in zebrafish early life stages. The Science of the total environment. 834:155433.
Abstract
In nature, the odorous substance β-ionone has been widely detected in aquatic ecosystems. However, little is known about its ecotoxicological effects on freshwater vertebrates. In this study, we aimed to assess the acute toxicity of β-ionone in zebrafish (Danio rerio) embryos from 2 to 120 h post fertilization (hpf) and investigate embryo development, locomotor behavior and pigmentation under different concentrations. The results showed that exposure to β-ionone had an acute toxicity to early life stages of zebrafish and induced a decrease in hatching rate and an increase in the mortality and malformation rate. The median lethal concentration (LC50) of β-ionone at 96 h was observed as 1321 μg/L. In addition, β-ionone not only affected the body length of zebrafish larvae but also regulated the transcription of genes and the levels of hormones involved in the growth hormone/insulin-like growth factor (GH/IGF) and the hypothalamic-pituitary-thyroid (HPT) axes. Moreover, exposure to β-ionone induced significant decreases in locomotor activity and catecholamine neurotransmitters levels. Furthermore, β-ionone stimulated pigmentation via regulation of tyrosinase activity and melanin-related gene expression. Overall, this research could provide new insights into the potential risk of odorants to aquatic organisms.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping