Gene

g6pd

ID
ZDB-GENE-070508-4
Name
glucose-6-phosphate dehydrogenase
Symbol
g6pd Nomenclature History
Previous Names
  • fj78b06
  • si:dkey-90a13.8
  • wu:fj78b06
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Enables UDP-glucose 6-dehydrogenase activity and glucose-6-phosphate dehydrogenase activity. Acts upstream of or within epiboly. Used to study hemolytic anemia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With g6pd Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital nonspherocytic hemolytic anemia Alliance Hemolytic anemia, G6PD deficient (favism) 300908
{Resistance to malaria due to G6PD deficiency} 611162
Associated With g6pd Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR019796 Glucose-6-phosphate dehydrogenase, active site
Domain IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding
Domain IPR022675 Glucose-6-phosphate dehydrogenase, C-terminal
Family IPR001282 Glucose-6-phosphate dehydrogenase
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Glucose-6-phosphate dehydrogenase Glucose-6-phosphate dehydrogenase, active site Glucose-6-phosphate dehydrogenase, C-terminal Glucose-6-phosphate dehydrogenase, NAD-binding NAD(P)-binding domain superfamily
UniProtKB:E7FDY7 513
UniProtKB:F6NHI0 523
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations