ZFIN

ZFIN ID: ZDB-GENE-040504-1

ZFIN ID: ZDB-GENE-040504-1

CITATIONS (53 total)

Gene Name:	nuclear receptor subfamily 1, group D, member 2a
Gene Symbol:	nr1d2a

He, X., Wang, Z., Cheng, L., Wang, H., Sun, Y. (2025) An antagonistic role of clock genes and lima1 in kidney regeneration. Communications biology. 8:2929

Lin, Q., Du, X., Ren, F., Liu, Y., Gong, G., Ge, S., Li, W., Li, Z., Zhou, L., Duan, M., Li, X.Y., Wang, G.Z., Xiao, R., Gui, J.F., Mei, J. (2025) Anti-Müllerian hormone signalling sustains circadian homeostasis in zebrafish. Nature communications. 16:43594359

Wu, J., Lin, X., Wu, D., Yan, B., Bao, M., Zheng, P., Wang, J., Yang, C., Li, Z., Jin, X., Jiang, K. (2023) Poly(I:C)-exposed zebrafish shows autism-like behaviors which are ameliorated by fabp2 gene knockout. Frontiers in molecular neuroscience. 15:10680191068019

Bolton, C.M., Bekaert, M., Eilertsen, M., Helvik, J.V., Migaud, H. (2021) Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain. Frontiers in Physiology. 12:761109

Zheng, X., Zhang, K., Zhao, Y., Fent, K. (2021) Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans. Environment International. 149:106159

Jaikumar, G., Slabbekoorn, H., Sireeni, J., Schaaf, M., Tudorache, C. (2020) The role of the Glucocorticoid Receptor in the Regulation of Diel Rhythmicity. Physiology & behavior. 223:112991

Faltermann, S., Hettich, T., Küng, N., Fent, K. (2019) Effects of the glucocorticoid clobetasol propionate and its mixture with cortisol and different class steroids in adult female zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 218:105372

Liang, Y.Q., Huang, G.Y., Zhen, Z., Tian, F., Hou, L., Lin, Z., Ying, G.G. (2019) The effects of binary mixtures of estradiol and progesterone on transcriptional expression profiles of genes involved in hypothalamic-pituitary-gonadal axis and circadian rhythm signaling in embryonic zebrafish (Danio rerio). Ecotoxicology and environmental safety. 174:540-548

Schmid, S., Willi, R.A., Salgueiro-González, N., Fent, K. (2019) Effects of new generation progestins, including as mixtures and in combination with other classes of steroid hormones, on zebrafish early life stages. The Science of the total environment. 709:136262

Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26

Willi, R., Castiglioni, S., Salgueiro Gonzalez, N., Furia, N., Mastroianni, S., Faltermann, S., Fent, K. (2019) Physiological and transcriptional effects of mixtures of environmental estrogens, androgens, progestins and glucocorticoids in zebrafish. Environmental science & technology. 54(2):1092-1101

Willi, R.A., Salgueiro-González, N., Faltermann, S., Hettich, T., Fent, K. (2019) Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos. The Science of the total environment. 672:183-191

Zhang, H., Chen, Z.F., Qi, Z., Yan, S.C., Wei, W.W., Liu, G., Cai, Z. (2019) ANALYSIS OF TRANSCRIPTIONAL RESPONSE IN ZEBRAFISH ELEUTHEROEMBRYOS EXPOSED TO CLIMBAZOLE: SIGNALING PATHWAYS AND POTENTIAL BIOMARKERS. Environmental toxicology and chemistry. 38(4):794-805

Geronikolou, S.A., Pavlopoulou, A., Kanaka-Gantenbein, C., Chrousos, G. (2018) Inter-species functional interactome of nuclear steroid receptors (R1). Frontiers in bioscience (Elite edition). 10:208-228

Zhao, Y., Zhang, K., Fent, K. (2018) Regulation of zebrafish (Danio rerio) locomotor behavior and circadian rhythm network by environmental steroid hormones. Environmental pollution (Barking, Essex : 1987). 232:422-429

Álvarez-Rodríguez, M., Pereiro, P., Reyes-López, F.E., Tort, L., Figueras, A., Novoa, B. (2018) Analysis of the Long-Lived Responses Induced by Immunostimulants and Their Effects on a Viral Infection in Zebrafish (Danio rerio).. Frontiers in immunology. 9:1575

Liang, Y.Q., Huang, G.Y., Zhao, J.L., Shi, W.J., Hu, L.X., Tian, F., Liu, S.S., Jiang, Y.X., Ying, G.G. (2017) Transcriptional alterations induced by binary mixtures of ethinylestradiol and norgestrel during the early development of zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 195:60-67

Siegenthaler, P.F., Bain, P., Riva, F., Fent, K. (2017) Effects of antiandrogenic progestins, chlormadinone and cyproterone acetate, and the estrogen 17α-ethinylestradiol (EE2), and their mixtures: Transactivation with human and rainbowfish hormone receptors and transcriptional effects in zebrafish (Danio rerio) eleuthero-embryos. Aquatic toxicology (Amsterdam, Netherlands). 182:142-162

Zhang, X., Zhou, Q., Zou, W., Hu, X. (2017) Molecular Mechanisms of Developmental Toxicity Induced by Graphene Oxide at Predicted Environmental Concentrations. Environmental science & technology. 51(14):7861-7871

Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37

Zhao, Y., Fent, K. (2016) Progestins alter photo-transduction cascade and circadian rhythm network in eyes of zebrafish (Danio rerio). Scientific Reports. 6:21559

Zhao, Y., Zhang, K., Fent, K. (2016) Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations. Environmental science & technology. 50(18):10245-54

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Zhao, Y., Castiglioni, S., Fent, K. (2015) Environmental progestins progesterone and drospirenone alter the circadian rhythm network in zebrafish (Danio rerio). Environmental science & technology. 49(16):10155-64

Zhao, Y., Zhang, K., Giesy, J.P., Hu, J. (2015) Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective. Scientific Reports. 5:8554

Ben-Moshe, Z., Alon, S., Mracek, P., Faigenbloom, L., Tovin, A., Vatine, G.D., Eisenberg, E., Foulkes, N.S., and Gothilf, Y. (2014) The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light. Nucleic acids research. 42(6):3750-67

Laranjeiro, R., Tamai, T.K., Peyric, E., Krusche, P., Ott, S., and Whitmore, D. (2013) Cyclin-dependent kinase inhibitor p20 controls circadian cell-cycle timing. Proceedings of the National Academy of Sciences of the United States of America. 110(17):6835-40

Amaral, I.P., and Johnston, I.A. (2012) Circadian expression of clock and putative clock-controlled genes in skeletal muscle of the zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 302(1):R193-206

Long, Y., Li, L., Li, Q., He, X., and Cui, Z. (2012) Transcriptomic characterization of temperature stress responses in larval zebrafish. PLoS One. 7(5):e37209

Bertrand, S., Thisse, B., Tavares, R., Sachs, L., Chaumot, A., Bardet, P.L., Escrivà, H., Duffraisse, M., Marchand, O., Safi, R., Thisse, C., and Laudet, V. (2007) Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. PLoS Genetics. 3(11):e188

Kakizawa, T., Nishio, S., Triqueneaux, G., Bertrand, S., Rambaud, J., and Laudet, V. (2007) Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erbalpha. Journal of molecular endocrinology. 38(5):555-568

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Robinson-Rechavi, M., Marchand, O., Escriva, H., Bardet, P.L., Zelus, D., Hughes, S., and Laudet, V. (2001) Euteleost fish genomes are characterized by expansion of gene families. Genome research. 11(5):781-788

Additional Citations (20):

Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

Thisse, C., and Thisse, B. (2008) Expression from: Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. ZFIN Direct Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.