ZFIN

ZFIN ID: ZDB-GENE-040426-2308

ZFIN ID: ZDB-GENE-040426-2308

CITATIONS (59 total)

Gene Name:	SIX homeobox 1b
Gene Symbol:	six1b

Duong, T.B., Fernandes, A.T., Ravisankar, P., Talbot, J.C., Waxman, J.S. (2025) Tbx1-dependent and independent pathways promote six gene expression downstream of retinoic acid signaling to determine cardiomyocyte number in zebrafish. Developmental Biology. :

Yu, T., Liu, X., Tan, X., Zhang, Y., He, Z., Yang, W., Tian, T., Li, Y., Zhao, J., Liu, C. (2025) Identification of renal stem cells in zebrafish. Science advances. 11:eadx5296eadx5296

Bell, J.M., Turner, E.M., Biesemeyer, C., Vanderbeck, M.M., Hendricks, R., McGraw, H.F. (2024) foxg1a is required for hair cell development and regeneration in the zebrafish lateral line. Biology Open. 13(9):

Liu, S., Xu, L., Kashima, M., Narumi, R., Takahata, Y., Nakamura, E., Shibuya, H., Tamura, M., Shida, Y., Inubushi, T., Nukada, Y., Miyazawa, M., Hata, K., Nishimura, R., Yamashiro, T., Tasaki, J., Kurosaka, H. (2024) Expression analysis of genes including Zfhx4 in mice and zebrafish reveals a temporospatial conserved molecular basis underlying craniofacial development. Developmental Dynamics : an official publication of the American Association of Anatomists. :

Miller, B.M., Goessling, W. (2024) The proteasome subunit psmb1 is essential for craniofacial cartilage maturation and morphogenesis. JCI insight. 9(16):

Yan, C.Y., Wu, F.Y., Sun, F., Fang, Y., Zhang, R.J., Zhang, C.R., Zhang, C.X., Wang, Z., Yang, R.M., Yang, L., Dong, M., Zhang, Q.Y., Ye, X.P., Song, H.D., Zhao, S.X. (2023) The isl2a transcription factor regulates pituitary development in zebrafish. Frontiers in endocrinology. 14:920548920548

Hsu, J.Y., Danis, E.P., Nance, S., O'Brien, J.H., Gustafson, A.L., Wessells, V.M., Goodspeed, A.E., Talbot, J.C., Amacher, S.L., Jedlicka, P., Black, J.C., Costello, J.C., Durbin, A.D., Artinger, K.B., Ford, H.L. (2022) SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state. Cell Reports. 38:110323

Sugasawa, T., Komine, R., Manevich, L., Tamai, S., Takekoshi, K., Kanki, Y. (2022) Gene Expression Profile Provides Novel Insights of Fasting-Refeeding Response in Zebrafish Skeletal Muscle. Nutrients. 14(11)

Pillay, S., Takahashi, H., Carninci, P., Kanhere, A. (2021) Antisense RNAs during early vertebrate development are divided in groups with distinct features. Genome research. 31(6):995-1010

Lang, I., Virk, G., Zheng, D.C., Young, J., Nguyen, M.J., Amiri, R., Fong, M., Arata, A., Chadaideh, K.S., Walsh, S., Weiser, D.C. (2020) The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. International Journal of Molecular Sciences. 21(16):

Talbot, J.C., Teets, E.M., Ratnayake, D., Duy, P.Q., Currie, P.D., Amacher, S.L. (2019) Muscle precursor cell movements in zebrafish are dynamic and require six-family genes. Development (Cambridge, England). 146(10):

Hung, K.S., Hsiao, C.C., Pai, T.W., Hu, C.H., Tzou, W.S., Wang, W.D., Chen, Y.R. (2018) Functional enrichment analysis based on long noncoding RNA associations. BMC systems biology. 12:45

Sharma, P., MacLean, A.L., Meinecke, L., Clouthier, D., Nie, Q., Schilling, T.F. (2018) Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis (New York, N.Y. : 2000). 57(1):e23275

Nakahara, Y., Muto, A., Hirabayashi, R., Sakuma, T., Yamamoto, T., Kume, S., Kikuchi, Y. (2016) Temporal effects of Notch signaling and potential cooperation with multiple downstream effectors on adenohypophysis cell specification in zebrafish. Genes to cells : devoted to molecular & cellular mechanisms. 21(5):492-504

Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Graf, M., Teo Qi-Wen, E.R., Viktor Sarusie, M., Rajaei, F., Winkler, C. (2015) Dmrt5 controls corticotrope and gonadotrope differentiation in the zebrafish pituitary. Molecular endocrinology (Baltimore, Md.). 29(2):187-99

Gómez-Marín, C., Tena, J.J., Acemel, R.D., López-Mayorga, M., Naranjo, S., de la Calle-Mustienes, E., Maeso, I., Beccari, L., Aneas, I., Vielmas, E., Bovolenta, P., Nobrega, M.A., Carvajal, J., Gómez-Skarmeta, J.L. (2015) Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Proceedings of the National Academy of Sciences of the United States of America. 112(24):7542-7

Ogawa, Y., Shiraki, T., Kojima, D., Fukada, Y. (2015) Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish. Proceedings. Biological sciences. 282(1812):20150659

O'Brien, J.H., Hernandez-Lagunas, L., Artinger, K.B., Ford, H.L. (2014) MicroRNA-30a regulates zebrafish myogenesis through targeting the transcription factor Six1. Journal of Cell Science. 127(Pt 10):2291-301

Talbot, J.C., Amacher, S.L. (2014) A Streamlined CRISPR Pipeline to Reliably Generate Zebrafish Frameshifting Alleles. Zebrafish. 11:583-585

Armant, O., März, M., Schmidt, R., Ferg, M., Diotel, N., Ertzer, R., Bryne, J.C., Yang, L., Baader, I., Reischl, M., Legradi, J., Mikut, R., Stemple, D., Ijcken, W.V., van der Sloot, A., Lenhard, B., Strähle, U., and Rastegar, S. (2013) Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Developmental Biology. 380(2):351-62

Lin, C.Y., Chen, J.S., Loo, M.R., Hsiao, C.C., Chang, W.Y., and Tsai, H.J. (2013) MicroRNA-3906 Regulates Fast Muscle Differentiation through Modulating the Target Gene homer-1b in Zebrafish Embryos. PLoS One. 8(7):e70187

Miyasaka, N., Wanner, A.A., Li, J., Mack-Bucher, J., Genoud, C., Yoshihara, Y., and Friedrich, R.W. (2013) Functional development of the olfactory system in zebrafish. Mechanisms of Development. 130(6-8):336-46

Nord, H., Skalman, L.N., and von Hofsten, J. (2013) Six1 regulates proliferation of Pax7-positive muscle progenitors in zebrafish. Journal of Cell Science. 126(Pt 8):1868-80

Mizoguchi, T., Togawa, S., Kawakami, K., and Itoh, M. (2011) Neuron and sensory epithelial cell fate is sequentially determined by notch signaling in zebrafish lateral line development. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(43):15522-15530

Li, Q., Ritter, D., Yang, N., Dong, Z., Li, H., Chuang, J.H., and Guo, S. (2010) A systematic approach to identify functional motifs within vertebrate developmental enhancers. Developmental Biology. 337(2):484-495

Henshall, T.L., Tucker, B., Lumsden, A.L., Nornes, S., Lardelli, M.T., and Richards, R.I. (2009) Selective neuronal requirement for Huntingtin in the developing zebrafish. Human molecular genetics. 18(24):4830-4842

Lin, C.Y., Chen, W.T., Lee, H.C., Yang, P.H., Yang, H.J., and Tsai, H.J. (2009) The transcription factor six1a plays an essential role in the craniofacial myogenesis of zebrafish. Developmental Biology. 331(2):152-166

Pogoda, H.M., and Hammerschmidt, M. (2009) How to make a teleost adenohypophysis: Molecular pathways of pituitary development in zebrafish. Molecular and Cellular Endocrinology. 312(1-2):2-13

Bessarab, D.A., Chong, S.W., Srinivas, B.P., and Korzh, V. (2008) Six1a is required for the onset of fast muscle differentiation in zebrafish. Developmental Biology. 323(2):216-228

Bricaud, O., and Collazo, A. (2006) The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(41):10438-10451

Nica, G., Herzog, W., Sonntag, C., Nowak, M., Schwarz, H., Zapata, A.G., Hammerschmidt, M. (2006) Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis. Developmental Biology. 292(1):189-204

Bessarab, D.A., Chong, S.W., and Korzh, V. (2004) Expression of zebrafish six1 during sensory organ development and myogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 230(4):781-786

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (24):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. Manually curated data.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

GOA, HGNC, AgBase and UniProtKB curators (2007) Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. ZFIN Direct Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.