Gene

six1b

ID
ZDB-GENE-040426-2308
Name
SIX homeobox 1b
Symbol
six1b Nomenclature History
Previous Names
  • six1 (1)
  • six1a (1)
  • zgc:77345 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including muscle organ development; nervous system development; and regulation of skeletal muscle cell proliferation. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Is expressed in several structures, including ectoderm; musculature system; nervous system; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 23; branchiootorenal syndrome; and nephroblastoma. Orthologous to human SIX1 (SIX homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
31 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With six1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 23 Alliance Deafness, autosomal dominant 23 605192
branchiootic syndrome Alliance Branchiootic syndrome 3 608389
Associated With six1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR031701 Homeobox protein SIX1, N-terminal SD domain
Family IPR031278 Homeobox protein SIX1
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Homeobox protein SIX1 Homeobox protein SIX1, N-terminal SD domain
UniProtKB:Q6NZ04 284
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations