Gene

six1b

ID

ZDB-GENE-040426-2308

Name

SIX homeobox 1b

Symbol

six1b Nomenclature History

Previous Names

six1 (1)
six1a (1)
zgc:77345 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including muscle organ development; nervous system development; and regulation of skeletal muscle cell proliferation. Predicted to localize to nucleus and transcription regulator complex. Is expressed in several structures, including ectoderm; musculature system; nervous system; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 23; branchiootorenal syndrome; and nephroblastoma. Orthologous to human SIX1 (SIX homeobox 1).

Genome Resources

Note

None

Expression

All Expression Data

31 figures from 13 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

MGC:77345 (28 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With six1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 23	Alliance	Deafness, autosomal dominant 23	605192
branchiootic syndrome	Alliance	Branchiootic syndrome 3	608389

Associated With six1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeobox domain
Domain	IPR031701	Homeobox protein SIX1, N-terminal SD domain
Family	IPR031278	Homeobox protein SIX1
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily