Gene
six1b
- ID
- ZDB-GENE-040426-2308
- Name
- SIX homeobox 1b
- Symbol
- six1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including muscle organ development; nervous system development; and regulation of skeletal muscle cell proliferation. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Is expressed in several structures, including ectoderm; musculature system; nervous system; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 23; branchiootorenal syndrome; and nephroblastoma. Orthologous to human SIX1 (SIX homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77345 (28 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 23 | Alliance | Deafness, autosomal dominant 23 | 605192 |
| branchiootic syndrome | Alliance | Branchiootic syndrome 3 | 608389 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox-like domain superfamily | Homeobox protein SIX1 | Homeobox protein SIX1, N-terminal SD domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6NZ04
|
284 |
Interactions and Pathways
No data available
Plasmids
No data available