Gene
six1b
- ID
- ZDB-GENE-040426-2308
- Name
- SIX homeobox 1b
- Symbol
- six1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nervous system development; pharyngeal muscle development; and skeletal muscle tissue development. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; cephalic musculature; ectoderm; peripheral nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 23; branchiootorenal syndrome; and nephroblastoma. Orthologous to human SIX1 (SIX homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77345 (28 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 23 | Alliance | Deafness, autosomal dominant 23 | 605192 |
| branchiootic syndrome | Alliance | Branchiootic syndrome 3 | 608389 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox-like domain superfamily | Homeobox protein SIX1 | Homeobox protein SIX1, N-terminal SD domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6NZ04
|
284 |
Interactions and Pathways
No data available
Plasmids
No data available