ZFIN

ZFIN ID: ZDB-GENE-030721-6

ZFIN ID: ZDB-GENE-030721-6

CITATIONS (76 total)

Gene Name:	myxovirus (influenza) resistance B
Gene Symbol:	mxb

Cao, L., Chang, M.X. (2025) Zebrafish CD44a variants suppress antiviral immunity through regulation of RIG-I ubiquitination and degradation. Fish & shellfish immunology. :110442110442

Wang, Z., Chen, X., Zhu, C., Fan, S., Tang, J., Deng, H., Sun, X., Liu, X., Xiao, W. (2025) Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity. Proceedings of the National Academy of Sciences of the United States of America. 122:e2320644122e2320644122

Pessoa Rodrigues, C., Collins, J.M., Yang, S., Martinez, C., Kim, J.W., Lama, C., Nam, A.S., Alt, C., Lin, C., Zon, L.I. (2024) Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells. Science (New York, N.Y.). 385:eadn1629eadn1629

Qu, Z.L., Gong, X.Y., An, L.L., Sun, H.Y., Guo, W.H., Luan, H.Y., Wu, M.Y., Dan, C., Gui, J.F., Zhang, Y.B. (2024) Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity. iScience. 27:109497109497

Wang, Z., Zhu, C., Sun, X., Deng, H., Liu, W., Jia, S., Bai, Y., Xiao, W., Liu, X. (2024) Spring viremia of carp virus infection induces hypoxia response in zebrafish by stabilizing hif1α. Journal of virology. :e0149124e0149124

Chen, L., Zhong, S., Wang, Y., Wang, X., Liu, Z., Hu, G. (2023) Bmp4 in Zebrafish Enhances Antiviral Innate Immunity through p38 MAPK (Mitogen-Activated Protein Kinases) Pathway. International Journal of Molecular Sciences. 24(19):

Xiong, S.T., Ying, Y.R., Long, Z., Li, J.H., Zhang, Y.B., Xiao, T.Y., Zhao, X. (2023) Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1. International journal of biological macromolecules. 240:124384

Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244

An, L.L., Zhao, X., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., Guo, W.H., Dan, C., Gui, J.F., Zhang, Y.B. (2022) Promoter Binding and Nuclear Retention Features of Zebrafish IRF Family Members in IFN Response. Frontiers in immunology. 13:861262

Gong, X.Y., Zhang, Q.M., Zhao, X., Li, Y.L., Qu, Z.L., Li, Z., Dan, C., Gui, J.F., Zhang, Y.B. (2022) LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response. iScience. 25:104821

Jiang, J., Gu, J., Zhan, A., Mao, M., Liu, Y., Wang, H., Mao, Y. (2022) Cloning, Exogenous Expression and Function Analysis of Interferon-γ from Gadus macrocephalus. Viruses. 14(10):

Liang, H., Li, Y., Li, M., Zhou, W., Chen, J., Zhang, Z., Yang, Y., Ran, C., Zhou, Z. (2022) The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. Frontiers in immunology. 13:1031962

Shin, K., Begeman, I.J., Cao, J., Kang, J. (2022) leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(1):91-106

Zhang, C., Zhao, Z., Zhang, P.Q., Guo, S., Zhu, B. (2022) TLR2-mediated mucosal immune priming boosts anti-rhabdoviral immunity in early vertebrates. Antiviral Research. 203:105346

Zhao, X., Dan, C., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., An, L.L., Guo, W.H., Gui, J.F., Zhang, Y.B. (2022) Zebrafish MARCH8 downregulates fish IFN response by targeting MITA and TBK1 for protein degradation. Developmental and comparative immunology. 135:104485

Wu, X.M., Fang, H., Zhang, J., Bi, Y.H., Chang, M.X. (2021) Histone H2A Nuclear/Cytoplasmic Trafficking Is Essential for Negative Regulation of Antiviral Immune Response and Lysosomal Degradation of TBK1 and IRF3. Frontiers in immunology. 12:771277

Liu, R., Hu, X., Lü, A., Song, Y., Lian, Z., Sun, J., Sung, Y.Y. (2020) Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response. Zebrafish. 17:91-103

Liu, W., Jin, Y., Zhang, W., Xiang, Y., Jia, P., Yi, M., Jia, K. (2020) MiR-202-5p Inhibits RIG-I-Dependent Innate Immune Responses to RGNNV Infection by Targeting TRIM25 to Mediate RIG-I Ubiquitination. Viruses. 12(3):

Wu, X.M., Zhang, J., Li, P.W., Hu, Y.W., Cao, L., Ouyang, S., Bi, Y.H., Nie, P., Chang, M.X. (2020) NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS. Journal of immunology (Baltimore, Md. : 1950). 204(8):2216-2231

Xiong, F., Cao, L., Wu, X.M., Chang, M.X. (2020) The function of zebrafish gpbar1 in antiviral response and lipid metabolism. Developmental and comparative immunology. 116:103955

Zhao, X., Gong, X.Y., Li, Y.L., Dan, C., Gui, J.F., Zhang, Y.B. (2020) Characterization of DNA Binding and Nuclear Retention Identifies Zebrafish IRF11 as a Positive Regulator of IFN Antiviral Response. Journal of immunology (Baltimore, Md. : 1950). 205(1):237-250

Cao, L., Wu, X.M., Nie, P., Chang, M.X. (2019) The negative regulation of piscine CD44c in viral and bacterial infection. Developmental and comparative immunology. 96:135-143

Gómez-Abenza, E., Ibáñez-Molero, S., García-Moreno, D., Fuentes, I., Zon, L.I., Mione, M.C., Cayuela, M.L., Gabellini, C., Mulero, V. (2019) Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment. Journal of experimental & clinical cancer research : CR. 38:405

Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26

Yu, G., Liu, X., Tang, J., Xu, C., Ouyang, G., Xiao, W. (2019) Neddylation Facilitates the Antiviral Response in Zebrafish. Frontiers in immunology. 10:1432

Hu, Y.W., Zhang, J., Wu, X.M., Cao, L., Nie, P., Chang, M.X. (2018) TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation. Frontiers in immunology. 9:84

Lai, Y., Liang, M., Hu, ., Zeng, Z., Lin, H., Yi, G., Li, M., Liu, Z. (2018) RNF135 is a positive regulator of IFN expression and involved in RIG-I signaling pathway by targeting RIG-I. Fish & shellfish immunology. 86:474-479

M, R., Medina-Gali, ., Belló-Pérez, M., Martínez-López, A., Falcó, A., Ortega-Villaizan, M.M., Encinar, J.A., Novoa, B., Coll, J., Perez, L. (2018) Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response. Fish & shellfish immunology. 82:514-521

Nikapitiya, C., Dananjaya, S.H.S., De Silva, B.C.J., Heo, G.J., Oh, C., De Zoysa, M., Lee, J. (2018) Chitosan nanoparticles: A positive immune response modulator as display in zebrafish larvae against Aeromonas hydrophila infection. Fish & shellfish immunology. 76:240-246

Robertsen, B., Greiner Tollersrud, L., Jørgensen, L.G. (2018) Analysis of the Atlantic salmon genome reveals a cluster of Mx genes that respond more strongly to IFN gamma than to type I IFN. Developmental and comparative immunology. 90:80-89

Chinchilla, B., Gomez-Casado, E. (2017) Identification of the functional regions of the viral haemorrhagic septicaemia virus (VHSV) NV protein: Variants that improve function. Fish & shellfish immunology. 70:343-350

García-Valtanen, P., Martínez-López, A., López-Muñoz, A., Bello-Perez, M., Medina-Gali, R.M., Ortega-Villaizán, M.D., Varela, M., Figueras, A., Mulero, V., Novoa, B., Estepa, A., Coll, J. (2017) Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes. Frontiers in immunology. 8:121

Huang, C.J., Chou, C.M., Lien, H.W., Chu, C.Y., Ho, J.Y., Wu, Y., Cheng, C.H. (2017) IRF9-Stat2 Fusion Protein as an Innate Immune Inducer to Activate Mx and Interferon-Stimulated Gene Expression in Zebrafish Larvae. Marine biotechnology (New York, N.Y.). 19(3):310-319

Rey, S., Moiche, V., Boltaña, S., Teles, M., MacKenzie, S. (2017) Behavioural fever in zebrafish larvae. Developmental and comparative immunology. 67:287-292

Zhang, Q.M., Zhao, X., Li, Z., Wu, M., Gui, J.F., Zhang, Y.B. (2017) Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response. Journal of immunology (Baltimore, Md. : 1950). 200(2):688-703

Espín-Palazón, R., Martínez-López, A., Roca, F.J., López-Muñoz, A., Tyrkalska, S.D., Candel, S., García-Moreno, D., Falco, A., Meseguer, J., Estepa, A., Mulero, V. (2016) TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response. PLoS pathogens. 12:e1005699

Zhang, L., Chen, W.Q., Hu, Y.W., Wu, X.M., Nie, P., Chang, M.X. (2016) TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish & shellfish immunology. 54:135-43

Candel, S., Sepulcre, M.P., Espín-Palazón, R., Tyrkalska, S.D., de Oliveira, S., Meseguer, J., Mulero, V. (2015) Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish. Developmental and comparative immunology. 50(2):155-65

Chen, H.Y., Liu, W., Wu, S.Y., Chiou, P.P., Li, Y.H., Chen, Y.C., Lin, G.H., Lu, M.W., Wu, J.L. (2015) RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells. Fish & shellfish immunology. 43(2):427-35

Chen, W.Q., Hu, Y.W., Zou, P.F., Ren, S.S., Nie, P., Chang, M.X. (2015) MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Developmental and comparative immunology. 49:19-30

Cobbina, S.J., Xu, H., Zhao, T., Mao, G., Zhou, Z., Wu, X., Liu, H., Zou, Y., Wu, X., Yang, L. (2015) A multivariate assessment of innate immune-related gene expressions due to exposure to low concentration individual and mixtures of four kinds of heavy metals on zebrafish (Danio rerio) embryos. Fish & shellfish immunology. 47(2):1032-42

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Estepa, A., Coll, J. (2015) Innate Multigene Family Memories Are Implicated in the Viral-Survivor Zebrafish Phenotype. PLoS One. 10:e0135483

López-Muñoz, A., Liarte, S., Gómez-González, N.E., Cabas, I., Meseguer, J., García-Ayala, A., Mulero, V. (2015) Estrogen receptor 2b deficiency impairs the antiviral response of zebrafish. Developmental and comparative immunology. 53(1):55-62

Zou, P.F., Chang, M.X., Li, Y., Zhang, S.H., Fu, J.P., Chen, S.N., Nie, P. (2015) Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish & shellfish immunology. 43(1):13-24

Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41

García-Valtanen, P., Martinez-Lopez, A., Ortega-Villaizan, M., Perez, L., Coll, J.M., and Estepa, A. (2014) In addition to its antiviral and immunomodulatory properties, the zebrafish Beta-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. Antiviral Research. 101:136-147

Nie, L., Xiong, R., Zhang, Y.S., Zhu, L.Y., Shao, J.Z., and Xiang, L.X. (2014) Conserved inhibitory role of teleost SOCS-1s in IFN signaling pathways. Developmental and comparative immunology. 43(1):23-29

Varela, M., Romero, A., Dios, S., van der Vaart, M., Figueras, A., Meijer, A.H., Novoa, B. (2014) Cellular Visualization of Macrophage Pyroptosis and Interleukin-1β Release in a Viral Hemorrhagic Infection in Zebrafish Larvae. Journal of virology. 88(20):12026-40

Huang, B., Huang, W.S., and Nie, P. (2013) Characterization of four Mx isoforms in the European eel, Anguilla anguilla. Fish & shellfish immunology. 35(3):1048-54

Galindo-Villegas, J., García-Moreno, D., de Oliveira, S., Meseguer, J., and Mulero, V. (2012) Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 109(39):E2605-2614

López-Muñoz, A., Sepulcre, M.P., Roca, F.J., Figueras, A., Meseguer, J., and Mulero, V. (2011) Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analysis. Molecular immunology. 48(9-10):1073-1083

Dios, S., Romero, A., Chamorro, R., Figueras, A., and Novoa, B. (2010) Effect Of The Temperature During Antiviral Immune Response Ontogeny In Teleosts. Fish & shellfish immunology. 29(6):1019-1027

Li, Z., Xu, X., Huang, L., Wu, J., Lu, Q., Xiang, Z., Liao, J., Weng, S., Yu, X., and He, J. (2010) Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish & shellfish immunology. 29(3):399-406

López-Muñoz, A., Roca, F.J., Sepulcre, M.P., Meseguer, J., and Mulero, V. (2010) Zebrafish Larvae Are Unable To Mount a Protective Antiviral Response Against Waterborne Infection by Spring Viremia of Carp Virus. Developmental and comparative immunology. 34(5):546-552

Mitra, S., Alnabulsi, A., Secombes, C.J., and Bird, S. (2010) Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio. The FEBS journal. 277(1):128-147

López-Muñoz, A., Roca, F.J., Meseguer, J., and Mulero, V. (2009) New insights into the evolution of IFNs: zebrafish Group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities. Journal of immunology (Baltimore, Md. : 1950). 182(6):3440-3449

Levraud, J.P., Boudinot, P., Colin, I., Benmansour, A., Peyriéras, N., Herbomel, P., and Lutfalla, G. (2007) Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System. Journal of immunology (Baltimore, Md. : 1950). 178(7):4385-4394

Lutfalla, G., Roest Crollius, H., Stange-Thomann, N., Jaillon, O., Mogensen, K., and Monneron, D. (2003) Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: The class II cytokine receptors and their ligands in mammals and fish. BMC Genomics. 4(1):29

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (16):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

Zebrafish Nomenclature Committee (2017) Nomenclature Data Curation (2017). Nomenclature Committee Submission.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. Manually curated data.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.