Gene
mxb
- ID
- ZDB-GENE-030721-6
- Name
- myxovirus (influenza) resistance B
- Symbol
- mxb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have GTPase activity and microtubule binding activity. Involved in response to virus. Predicted to localize to several cellular components, including dendritic spine head; postsynaptic density; and postsynaptic endocytic zone membrane. Orthologous to human MX1 (MX dynamin like GTPase 1) and MX2 (MX dynamin like GTPase 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 12 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Dynamin | Dynamin, GTPase domain | Dynamin GTPase effector | Dynamin, GTPase region, conserved site | Dynamin, N-terminal | Dynamin stalk domain | Dynamin-type guanine nucleotide-binding (G) domain | GTPase effector domain | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:B8JKI4
|
627 | |||||||||
UniProtKB:B3DH90
|
550 | |||||||||
UniProtKB:Q800G8
|
627 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-197A6 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194096 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194116 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001128672 (1) | 1819 nt | ||
Genomic | GenBank:CT998565 (1) | 169303 nt | ||
Polypeptide | UniProtKB:B8JKI4 (1) | 627 aa |
No data available
- Qu, Z.L., Gong, X.Y., An, L.L., Sun, H.Y., Guo, W.H., Luan, H.Y., Wu, M.Y., Dan, C., Gui, J.F., Zhang, Y.B. (2024) Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity. iScience. 27:109497109497
- Chen, L., Zhong, S., Wang, Y., Wang, X., Liu, Z., Hu, G. (2023) Bmp4 in Zebrafish Enhances Antiviral Innate Immunity through p38 MAPK (Mitogen-Activated Protein Kinases) Pathway. International Journal of Molecular Sciences. 24(19):
- Xiong, S.T., Ying, Y.R., Long, Z., Li, J.H., Zhang, Y.B., Xiao, T.Y., Zhao, X. (2023) Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1. International journal of biological macromolecules. 240:124384
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- An, L.L., Zhao, X., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., Guo, W.H., Dan, C., Gui, J.F., Zhang, Y.B. (2022) Promoter Binding and Nuclear Retention Features of Zebrafish IRF Family Members in IFN Response. Frontiers in immunology. 13:861262
- Gong, X.Y., Zhang, Q.M., Zhao, X., Li, Y.L., Qu, Z.L., Li, Z., Dan, C., Gui, J.F., Zhang, Y.B. (2022) LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response. iScience. 25:104821
- Jiang, J., Gu, J., Zhan, A., Mao, M., Liu, Y., Wang, H., Mao, Y. (2022) Cloning, Exogenous Expression and Function Analysis of Interferon-γ from Gadus macrocephalus. Viruses. 14(10):
- Liang, H., Li, Y., Li, M., Zhou, W., Chen, J., Zhang, Z., Yang, Y., Ran, C., Zhou, Z. (2022) The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. Frontiers in immunology. 13:1031962
- Shin, K., Begeman, I.J., Cao, J., Kang, J. (2022) leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(1):91-106
- Zhao, X., Dan, C., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., An, L.L., Guo, W.H., Gui, J.F., Zhang, Y.B. (2022) Zebrafish MARCH8 downregulates fish IFN response by targeting MITA and TBK1 for protein degradation. Developmental and comparative immunology. 135:104485
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