ZFIN

ZFIN ID: ZDB-GENE-020220-1

ZFIN ID: ZDB-GENE-020220-1

CITATIONS (70 total)

Gene Name:	amyloid beta (A4) precursor protein b
Gene Symbol:	appb

Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.

Rahmati, M., Chebli, J., Banote, R.K., Roselli, S., Agholme, L., Zetterberg, H., Abramsson, A. (2024) Fine-tuning amyloid precursor protein expression through non-sense mediated mRNA decay. eNeuro. 11(6):

Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.

Özcan, G.G., Lim, S., Canning, T., Tirathdas, L., Donnelly, J., Kundu, T., Rihel, J. (2024) Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance. iScience. 27:108870108870

Park, J., Kim, D.Y., Hwang, G.S., Han, I.O. (2023) Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer's disease neuropathology in adult zebrafish. Journal of neuroinflammation. 20:257257

Wei, J., Wang, X., Dong, Y., Zhong, X., Ren, X., Song, R., Ma, J., Yu, A., Fan, Q., Yao, J., Shan, D., Lv, F., Zheng, Y., Deng, Q., Li, X., He, Y., Fan, S., Zhao, C., Wang, X., Yuan, R., She, G. (2022) Curcumae Rhizoma - combined with Sparganii Rhizoma in the treatment of liver cancer: Chemical analysis using UPLC-LTQ-Orbitrap MSⁿ, network analysis, and experimental assessment. Frontiers in pharmacology. 13:10276871027687

Capriello, T., Monteiro, S.M., Félix, L.M., Donizetti, A., Aliperti, V., Ferrandino, I. (2021) Apoptosis, oxidative stress and genotoxicity in developing zebrafish after aluminium exposure. Aquatic toxicology (Amsterdam, Netherlands). 236:105872

Chebli, J., Rahmati, M., Lashley, T., Edeman, B., Oldfors, A., Zetterberg, H., Abramsson, A. (2021) The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish. Scientific Reports. 11:19115

Karuppan, S.J., Vogt, A., Fischer, Z., Ladutska, A., Swiastyn, J., McGraw, H.F., Bouyain, S. (2021) Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface. The Journal of biological chemistry. 298(2):101541

Banote, R.K., Chebli, J., Şatır, T.M., Varshney, G.K., Camacho, R., Ledin, J., Burgess, S.M., Abramsson, A., Zetterberg, H. (2020) Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish. Scientific Reports. 10:10127

Barthelson, K., Pederson, S.M., Newman, M., Lardelli, M. (2020) Brain Transcriptome Analysis of a Protein-Truncating Mutation in Sortilin-Related Receptor 1 Associated With Early-Onset Familial Alzheimer's Disease Indicates Early Effects on Mitochondrial and Ribosome Function. Journal of Alzheimer's disease : JAD. 79(3):1105-1119

Sharma, C., Kang, S.C. (2020) Garcinol pacifies acrylamide induced cognitive impairments, neuroinflammation and neuronal apoptosis by modulating GSK signaling and activation of pCREB by regulating cathepsin B in the brain of zebrafish larvae. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 138:111246

Meguro, S., Hosoi, S., Hasumura, T. (2019) High-fat diet impairs cognitive function of zebrafish. Scientific Reports. 9:17063

Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5

Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613

Lee, J., Peterson, S.M., Freeman, J.L. (2017) Sex-specific characterization and evaluation of the Alzheimer's disease genetic risk factor sorl1 in zebrafish during aging and in the adult brain following a 100 ppb embryonic lead exposure. Journal of applied toxicology : JAT. 37(4):400-407

Banote, R.K., Edling, M., Eliassen, F., Kettunen, P., Zetterberg, H., Abramsson, A. (2016) β-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notch-dependent manner. Developmental Biology. 413(1):26-38

Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37

Lee, J., Freeman, J.L. (2016) Embryonic exposure to 10 μg L(-1) lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer's disease in aged adult zebrafish brain. Metallomics : integrated biometal science. 8(6):589-96

Lee, J., Peterson, S.M., Freeman, J.L. (2016) Alzheimer's disease risk genes in wild-type adult zebrafish exhibit gender-specific expression changes during aging. Neurogenetics. 17(3):197-9

Wang, X., Zheng, Y., Zhang, Y., Li, J., Zhang, H., Wang, H. (2016) Effects of β-diketone antibiotic mixtures on behavior of zebrafish (Danio rerio). Chemosphere. 144:2195-2205

Gao, D., Wu, M., Wang, C., Wang, Y., Zuo, Z. (2015) Chronic exposure to low benzo[a]pyrene level causes neurodegenerative disease-like syndromes in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 167:200-208

Nicolas, M., Hassan, B.A. (2014) Amyloid precursor protein and neural development. Development (Cambridge, England). 141:2543-8

Abramsson, A., Kettunen, P., Banote, R.K., Lott, E., Li, M., Arner, A., and Zetterberg, H. (2013) The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation. Developmental Biology. 381(2):377-88

Fleisch, V.C., Leighton, P.L., Wang, H., Pillay, L.M., Ritzel, R.G., Bhinder, G., Roy, B., Tierney, K.B., Ali, D.W., Waskiewicz, A.J., and Allison, W.T. (2013) Targeted Mutation of the Gene Encoding Prion Protein in Zebrafish reveals a Conserved Role in Neuron Excitability. Neurobiology of disease. 55:11-25

Hogl, S., van Bebber, F., Dislich, B., Kuhn, P.H., Haass, C., Schmid, B., and Lichtenthaler, S.F. (2013) Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics. 13(9):1519-27

Luna, S., Cameron, D.J., and Ethell, D.W. (2013) Amyloid-beta and APP Deficiencies Cause Severe Cerebrovascular Defects: Important Work for an Old Villain. PLoS One. 8(9):e75052

Mora, N., Almudi, I., Alsina, B., Corominas, M., and Serras, F. (2013) The Beta-amyloid protein precursor like (Appl) is a Ras1/MAPK regulated gene required for axonal targeting in Drosophila photoreceptor neurons. The Journal of cell biology. 126(1):53-59

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Wilson, L., and Lardelli, M. (2013) The Development of an in vivo gamma-Secretase Assay using Zebrafish Embryos. Journal of Alzheimer's disease : JAD. 36(3):521-34

Kaiser, D.M., Acharya, M., Leighton, P.L., Wang, H., Daude, N., Wohlgemuth, S., Shi, B., and Allison, W.T. (2012) Amyloid Beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development. PLoS One. 7(12):e51305

Liao, H.K., Wang, Y., Watt, K.E., Wen, Q., Breitback, J., Kemmet, C.K., Clark, K.J., Ekker, S.C., Essner, J.J., and McGrail, M. (2012) Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(2):415-425

Nik, S.H., Wilson, L., Newman, M., Croft, K., Mori, T.A., Musgrave, I., and Lardelli, M. (2012) The BACE1-PSEN-AbetaPP Regulatory Axis has an Ancient Role in Response to Low Oxygen/Oxidative Stress. Journal of Alzheimer's disease : JAD. 28(3):515-530

Shakes, L.A., Du, H., Wolf, H.M., Hatcher, C., Norford, D.C., Precht, P., Sen, R., and Chatterjee, P.K. (2012) Using BAC transgenesis in zebrafish to identify regulatory sequences of the amyloid precursor protein gene in humans. BMC Genomics. 13(1):451

Song, P., and Pimplikar, S.W. (2012) Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth. PLoS One. 7(4):e34209

Tam, S.J., Richmond, D.L., Kaminker, J.S., Modrusan, Z., Martin-McNulty, B., Cao, T.C., Weimer, R.M., Carano, R.A., van Bruggen, N., and Watts, R.J. (2012) Death Receptors DR6 and TROY Regulate Brain Vascular Development. Developmental Cell. 22(2):403-417

Shakes, L.A., Abe, G., Eltayeb, M.A., Wolf, H.M., Kawakami, K., and Chatterjee, P.K. (2011) Generating libraries of iTol2-end insertions at BAC ends using loxP and lox511 Tn10 transposons. BMC Genomics. 12(1):351

Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677

Martin, S., Söllner, C., Charoensawan, V., Adryan, B., Thisse, B., Thisse, C., Teichmann, S.A., and Wright, G.J. (2010) Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Molecular & cellular proteomics : MCP. 9(12):2654-2665

Joshi, P., Liang, J.O., Dimonte, K., Sullivan, J., and Pimplikar, S.W. (2009) Amyloid precursor protein is required for convergent-extension movements during Zebrafish development. Developmental Biology. 335(1):1-11

Shakes, L.A., Malcolm, T.L., Allen, K.L., De, S., Harewood, K.R., and Chatterjee, P.K. (2008) Context dependent function of APPb enhancer identified using enhancer trap-containing BACs as transgenes in zebrafish. Nucleic acids research. 36(19):6237-6248

Lee, J.A., and Cole, G.J. (2007) Generation of transgenic zebrafish expressing green fluorescent protein under control of zebrafish amyloid precursor protein gene regulatory elements. Zebrafish. 4(4):277-286

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Musa, A., Lehrach, H., and Russo, V.E.A. (2001) Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development. Development genes and evolution. 211(11):563-567

Additional Citations (25):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2003) Computational Sequence to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.