ZFIN Morpholino: MO3-isl1a

Target Location

Genome Build: GRCz11Chromosome: 5

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-isl1a

Expressed Gene	Anatomy	Figures
nrp1a	CaP motoneuron primary motor neuron	Fig. 1 from Moreno et al., 2014
olig4	(not) Rohon-Beard neuron spinal cord interneuron	Fig. 3 from Moreno et al., 2014
runx3	Rohon-Beard neuron	Fig. 3 from Moreno et al., 2014
scn8aa	Rohon-Beard neuron	Fig. 6 from Moreno et al., 2014

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Phenotype

Phenotype resulting from MO3-isl1a

Phenotype	Fish	Figures
CaP motoneuron membrane repolarization process quality, abnormal	WT + MO3-isl1a	Fig. 7 from Moreno et al., 2014
CaP motoneuron neuron projection displaced, abnormal	js12Tg + MO3-isl1a	Fig. 1 from Moreno et al., 2014
CaP motoneuron neuron projection morphology, abnormal	js12Tg + MO3-isl1a	Fig. 1 from Moreno et al., 2014
CaP motoneuron neuronal action potential process quality, abnormal	ml2Tg + MO3-isl1a	Fig. 4, Fig. 7 from Moreno et al., 2014
dorsal root ganglion decreased amount, abnormal	sb4Tg + MO3-isl1a	Fig. 3 from Moreno et al., 2014

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Phenotype of all Fish created by or utilizing MO3-isl1a

Phenotype	Fish	Conditions	Figures
motor neuron axon mislocalised posteriorly, abnormal	AB + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 4 from Hutchinson et al., 2006
VeLD increased amount, abnormal	AB + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 4 from Hutchinson et al., 2006
Kolmer-Agduhr neuron increased amount, abnormal	AB + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 4 from Hutchinson et al., 2006
secondary motor neuron decreased amount, abnormal	WT + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 3 from Hutchinson et al., 2006
MiP motor neuron axon absent, abnormal	WT + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 2 from Hutchinson et al., 2006

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Citations

Include unpublished citations

Moreno, R.L., Ribera, A.B. (2014) Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability. Neural Development. 9:19
Seredick, S., Hutchinson, S.A., Van Ryswyk, L., Talbot, J.C., Eisen, J.S. (2014) Lhx3 and Lhx4 suppress Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons. Development (Cambridge, England). 141(20):3900-9
Wang, L., Mongera, A., Bonanomi, D., Cyganek, L., Pfaff, S.L., Nüsslein-Volhard, C., Marquardt, T. (2014) A conserved axon type hierarchy governing peripheral nerve assembly. Development (Cambridge, England). 141:1875-83
Seredick, S., Van Ryswyk, L., Hutchinson, S.A., and Eisen, J.S. (2012) Zebrafish Mnx proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics. Neural Development. 7(1):35
Witzel, H.R., Jungblut, B., Choe, C.P., Crump, J.G., Braun, T., and Dobreva, G. (2012) The LIM Protein Ajuba Restricts the Second Heart Field Progenitor Pool by Regulating Isl1 Activity. Developmental Cell. 23(1):58-70
Lim, A.H., Suli, A., Yaniv, K., Weinstein, B., Li, D.Y., and Chien, C.B. (2011) Motoneurons are essential for vascular pathfinding. Development (Cambridge, England). 138(17):3847-3857
de Pater, E., Clijsters, L., Marques, S.R., Lin, Y.F., Garavito-Aguilar, Z.V., Yelon, D., and Bakkers, J. (2009) Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart. Development (Cambridge, England). 136(10):1633-1641
Hutchinson, S.A., and Eisen, J.S. (2006) Islet1 and Islet2 have equivalent abilities to promote motoneuron formation and to specify motoneuron subtype identity. Development (Cambridge, England). 133(11):2137-2147

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