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Xue et al., 2019 - Zebrafish Vestigial Like Family Member 4b Is Required for Valvulogenesis Through Sequestration of Transcription Factor Myocyte Enhancer Factor 2c

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FIGURE 2

Deficiency of zebrafish vgll4b leads to impaired valvulogenesis. (A–D) WISH analysis of cmcl2 expression in zebrafish embryos at 22, 36, 48, and 96 hpf, a defective S shaped heart looping was clearly observed from 36 hpf. White dashed lines indicate the heart morphology outlined by cmlc2 expression. Lateral view, (C). (E–K) WISH analysis of vmhc, amhc, anf at 48 hpf, as well as bmp4, notch1b, klf2a, spp1 at 52 hpf. (L,M) Optical Heartbeat analysis of cardiac function. Comparison of the heart rate at 48 hpf (L) and ventricular shortening fraction at 52∼54 hfp (M). (N,O) Representative single confocal z-section images showing the endocardial cushion cells expressing Alcam (asterisks) of wild type sibling and vgll4b^–/– embryos at 52 hpf. Scale bar: 10 μm.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol