ZFIN ID: ZDB-GENE-980528-2059
Gene Name: bone morphogenetic protein 4
Gene Symbol: bmp4    Nomenclature History

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Previous Names: bmp-4, zbmp-4, etID309887.17 (1), zgc:100779

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have cytokine activity and transforming growth factor beta receptor binding activity. Involved in several processes, including animal organ development; determination of bilateral symmetry; and regulation of transcription by RNA polymerase II. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Is expressed in several structures, including fin; head; inner ear; mesoderm; and pericardial region. Orthologous to human BMP4 (bone morphogenetic protein 4).
Genome Resources: Alliance (1),  Gene:30612 (1),  Ensembl(GRCz11):ENSDARG00000019995 (2)
GENE EXPRESSION
All Expression Data: 274 figures from 213 publications
Directly Submitted Expression Data: 7 figures (27 images) from Thisse et al., 2005 [eu728]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1149 Point Mutation Unknown Missense ENU
b1150 Point Mutation Unknown Premature Stop ENU
b1172 Point Mutation Unknown Premature Stop ENU
la010179Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la013167Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36537 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • st37 Insertion Unknown Unknown
    st72 Point Mutation Exon 4 Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bmp4 N/A 10
    MO2-bmp4 N/A 2
    MO3-bmp4 N/A 12
    MO4-bmp4 N/A 1
    DISEASE ASSOCIATED WITH bmp4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    orofacial cleft 11 Alliance Orofacial cleft 11 600625
    syndromic microphthalmia Alliance Microphthalmia, syndromic 6 607932
    DISEASE ASSOCIATED WITH bmp4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of ventral identity (more)
    Cellular Component extracellular region (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 32)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017948 Transforming growth factor beta, conserved site
    Domain IPR001111 TGF-beta, propeptide
    Domain IPR001839 Transforming growth factor-beta, C-terminal
    Family IPR015615 Transforming growth factor-beta-related
    Homologous_superfamily IPR029034 Cystine-knot cytokine
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bmp4-201 (1)    Ensembl 2991
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bmp4
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-7.5bmp4:GFP) bmp4 GFP Danio rerio 2 10
    Tg(hsp70l:bmp4,myl7:EGFP) hsp70lmyl7 bmp4EGFP Danio rerio 1 2
    Tg(hsp70l:GAL4,UAS:bmp4) hsp70lUAS bmp4GAL4 Danio rerio 1 1
    Tg(Ola.Rx2:bmp4,myl7:EGFP) myl7 bmp4EGFP Danio rerioOryzias latipes 1 2
    Tg(UAS:bmp4,myl7:EGFP) myl7 bmp4EGFP Danio rerio 1 8
    MARKER RELATIONSHIPS
    bmp4 Contained in: [BAC] CH73-374D11 (1), CH211-287A24 (1)
    bmp4 Encodes: [EST] eu728 (1)
    [cDNA] MGC:100779 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131342 (1) 2985 nt
    Genomic GenBank:CR391996 (1) 66448 nt
    Select Tool
    Polypeptide UniProtKB:F1QAD6 (1) 400 aa
    Sequence Information (all 27)
    ORTHOLOGY for bmp4 ( Chr: 17 )
    CITATIONS (434)