Gene

bmp4

ID
ZDB-GENE-980528-2059
Name
bone morphogenetic protein 4
Symbol
bmp4 Nomenclature History
Previous Names
  • bmp-4
  • zbmp-4
  • etID309887.17 (1)
  • zgc:100779
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have BMP receptor binding activity and cytokine activity. Involved in several processes, including animal organ development; determination of bilateral symmetry; and embryonic morphogenesis. Predicted to localize to extracellular space. Is expressed in several structures, including cardiovascular system; fin; head; inner ear; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4).
Genome Resources
Note
None
Expression
All Expression Data
276 figures from 215 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bmp4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
orofacial cleft 11 Alliance Orofacial cleft 11 600625
syndromic microphthalmia 6 Alliance Microphthalmia, syndromic 6 607932
Associated With bmp4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:P87380 391
UniProtKB:O13107 400
UniProtKB:F1QAD6 400
UniProtKB:O57574 400
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations