ZFIN ID: ZDB-GENE-011109-1
Gene Name: Kruppel-like factor 2a
Gene Symbol: klf2a    Nomenclature History

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Previous Names: etID35223.22 (1), fb08e06, wu:fb08e06 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Exhibits transcription regulatory region DNA binding activity. Involved in circulatory system development; nitric oxide biosynthetic process; and regulation of cell fate specification. Predicted to localize to nucleus. Is expressed in several structures, including EVL; cardiovascular system; cloaca; fin; and pectoral fin bud. Orthologous to human KLF2 (Kruppel like factor 2).
Genome Resources: Alliance (1),  Gene:117508 (1),  Ensembl(GRCz11):ENSDARG00000042667 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns11 Small Deletion Unknown Unknown TALEN
ig4 Indel Exon 1 Premature Stop TALEN
sa24120 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30728 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sh317 Small Deletion Exon 2 Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-klf2a
    2
    MO1-klf2a N/A 8
    MO2-klf2a N/A 4
    MO3-klf2a N/A 3
    MO4-klf2a N/A 3
    MO5-klf2a N/A 1
    MO6-klf2a N/A 1
    TALEN1-klf2a 1
    TALEN2-klf2a 1
    TALEN3-klf2a 1
    DISEASE ASSOCIATED WITH klf2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH klf2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function transcription regulatory region sequence-specific DNA binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA klf2a-201 (1)    Ensembl 2180
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM klf2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:klf2a,EGFP) hsp70l EGFPklf2a Danio rerio 1 3
    Tg(hsp70l:klf2a-IRES-EGFP) hsp70l EGFPIRESklf2a Danio rerio 1 1
    Tg(klf2a:H2b-EGFP) klf2a EGFP Danio rerio 1 4
    tg(myl7:klf2a-2a-tdtomato) myl7 2Aklf2aTomato Danio rerio 1 1
    Tg(UAS:klf2a) UAS klf2a Danio rerio 3 3
    TgBAC(klf2a:Citrine) klf2a Citrine Danio rerio 1 2
    MARKER RELATIONSHIPS
    klf2a Contained in: [BAC] CH211-171D11 (1), DKEY-192M14 (1) (order this), DKEYP-70F9 (1)
    klf2a Encodes: [EST] fb08e06 (1)
    [cDNA] MGC:77570 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131856 (1) 2133 nt
    Genomic GenBank:BX323550 (1) 200031 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q1LXI7 (1) 380 aa
    Sequence Information (all 16)
    ORTHOLOGY for klf2a ( Chr: 22 )
    CITATIONS (88)