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ZIRC
ZFIN ID: ZDB-GENE-050706-97
Gene Name: secreted phosphoprotein 1
Gene Symbol: spp1    Nomenclature History

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Previous Names: osteopontin (1), zgc:111821

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Involved in bone development. Human ortholog(s) of this gene implicated in several diseases, including biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); multiple sclerosis; and rheumatoid arthritis. Is expressed in several structures, including cranium; heart; opercular flap; osteoblast; and pectoral fin. Orthologous to human SPP1 (secreted phosphoprotein 1).
Genome Resources: Alliance (1),  Gene:432385 (1),  Ensembl(GRCz11):ENSDARG00000044276 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa38784 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-spp1
    1
    CRISPR2-spp1
    1
    CRISPR3-spp1
    2
    MO1-spp1 N/A 1
    MO2-spp1 N/A 1
    DISEASE ASSOCIATED WITH spp1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH spp1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process bone development (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002038 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA spp1-201 (1)    Ensembl 1503
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM spp1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(spp1:EGFP) spp1 EGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    spp1 Contained in: [BAC] DKEY-272D15 (1) (order this)
    spp1 Encodes: [cDNA] MGC:111821 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002308 (1) 1482 bp
    Genomic GenBank:CR925756 (1) 107798 bp
    Select Tool
    Polypeptide UniProtKB:F1Q9F4 (1) 305 aa
    Sequence Clusters UniGene:85739 (1)
    Sequence Information (all 16)
    ORTHOLOGY for spp1 ( Chr: 10 )
    CITATIONS (69)