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Gene

nppa

ID
ZDB-GENE-030131-95
Name
natriuretic peptide A
Symbol
nppa Nomenclature History
Previous Names
  • anf (1)
  • anp (1)
  • atrial natriuretic factor (1)
  • hm:zeh1304
  • zeh1304
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable hormone activity and hormone receptor binding activity. Acts upstream of or within atrioventricular canal development; cardiac jelly development; and cardiac muscle cell proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm; extracellular space; and nucleus. Is expressed in heart rudiment; pericardial region; and skeletal muscle cell. Human ortholog(s) of this gene implicated in artery disease (multiple); congestive heart failure; heart conduction disease (multiple); and peritonitis. Orthologous to human NPPA (natriuretic peptide A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
110 figures from 76 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nppa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
atrial standstill 2 Alliance Atrial standstill 2 615745
familial atrial fibrillation Alliance Atrial fibrillation, familial, 6 612201
Associated With nppa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030480 Natriuretic peptide, conserved site
Family IPR000663 Natriuretic peptide
Domain Details Per Protein
Protein Length Natriuretic peptide Natriuretic peptide, conserved site
UniProtKB:Q6VYM3 106
UniProtKB:F1QVW0 139
UniProtKB:Q0PNB5 122
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations