ZFIN Image: Park et al., 2019, Fig. 5

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Figure Caption

Fig. 5

Sphk2 deletion suppresses liver defects in the kdsr^I105R mutant. Images of live wild type (wt), kdsr^I105R, and kdsr^I105R; sphk2^wc1 double mutant at 7 dpf (A). Scale bar = 0.25 mm. Relative mRNA expression of sphk2 and other genes associated with inflammation (tnfa, il1b), tissue injury (alpha1-anti-trypsin (a1at)) and fibrosis (col1a1a) (B), sphingolipid salvage pathway related genes (C) in wt, kdsr^I105R, sphk2^wc1, and kdsr^I105R; sphk2^wc1 mutant siblings. spp1, (S1P-phosphohydrolase 1). Images of H&E and ORO staining in livers of wt, kdsr^I105R and kdsr^I105R; sphk2^wc1double mutants (D, n = 6). Error bars indicate standard deviation of the mean. *P ≤ 0.05, **P ≤ 0.005. Scale bare in D = 100 µm.

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Acknowledgments

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