ZFIN ID: ZDB-GENE-030131-1421
Gene Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Gene Symbol: serpina1
Sequence Ontology ID : SO:0000704

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Previous Names: wu:fb61c07, wu:fb71a09, zgc:153807, zgc:158145

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have serine-type endopeptidase inhibitor activity; predicted to be involved in negative regulation of endopeptidase activity; predicted to localize to the extracellular space;  ...
GENE EXPRESSION
All Expression Data: text only from Andreeva et al., 2015
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH serpina1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
alpha 1-antitrypsin deficiency Emphysema due to AAT deficiency 613490
Emphysema-cirrhosis, due to AAT deficiency 613490
Hemorrhagic diathesis due to antithrombin Pittsburgh 613490
chronic obstructive pulmonary disease {Pulmonary disease, chronic obstructive, susceptibility to} 606963
DISEASE ASSOCIATED WITH serpina1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component extracellular space (more)
Molecular Function serine-type endopeptidase inhibitor activity (more)
GO Terms (all 2)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000215 (1)
  • InterPro:IPR023795 (1)
  • InterPro:IPR023796 (1)
  • InterPro:IPR036186 (1)
  • PROSITE:PS00284 (1)
  • Pfam:PF00079 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA serpina1-201 (1) 1650
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM serpina1 No data available
    MARKER RELATIONSHIPS
    serpina1Contained in: [BAC] CH211-121D13 (order this)
    serpina1Encodes: [EST] fb61c07, fb71a09, IMAGE:6997096
    [cDNA] MGC:153807 (1) (order this), MGC:158145 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001077758 (1) 1448bp
    Genomic GenBank:AL845550 (1) 163676bp
    Select Tool
    Polypeptide UniProtKB:Q6P5I9 (1) 435aa
    Sequence Clusters UniGene:75688 (1)
    Sequence Information (all 29)
    OTHER serpina1 GENE PAGES
  • Alliance (1)
  • Gene:322701 (1)
  • VEGA:OTTDARG00000004306 (1)
  • Ensembl(GRCz11):ENSDARG00000090286 (2)
  • ORTHOLOGY for serpina1 (Chr: 20)
    CITATIONS (23)