Gene

sphk2

ID
ZDB-GENE-100922-225
Name
sphingosine kinase 2
Symbol
sphk2 Nomenclature History
Previous Names
  • si:dkey-40m6.13 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have D-erythro-sphingosine kinase activity and lipid kinase activity. Involved in several processes, including animal organ development; cellular response to ceramide; and sphingolipid mediated signaling pathway. Predicted to localize to cytoplasm; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including blastodisc; heart; liver; pleuroperitoneal region; and yolk syncytial layer. Used to study non-alcoholic steatohepatitis. Orthologous to human SPHK2 (sphingosine kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sphk2 Human Ortholog
No data available
Associated With sphk2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001206 Diacylglycerol kinase, catalytic domain
Homologous_superfamily IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
Homologous_superfamily IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
Domain Details Per Protein
Protein Length Diacylglycerol kinase, catalytic domain Inorganic polyphosphate/ATP-NAD kinase, N-terminal NAD kinase/diacylglycerol kinase-like domain superfamily
UniProtKB:A0A0R4IC42 869
UniProtKB:F1QWD8 738
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations