Gene
sphk2
- ID
- ZDB-GENE-100922-225
- Name
- sphingosine kinase 2
- Symbol
- sphk2 Nomenclature History
- Previous Names
-
- si:dkey-40m6.13 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have NAD+ kinase activity. Involved in animal organ development; cellular response to ceramide; and sphingosine metabolic process. Used to study non-alcoholic steatohepatitis. Is expressed in several structures, including blastodisc; heart; liver; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human SPHK2 (sphingosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| metabolic dysfunction-associated steatohepatitis | sphk2wcm2/wcm2 (AB/TU) | standard conditions | Park et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001206 | Diacylglycerol kinase, catalytic domain |
| Domain | IPR045540 | YegS/DAGK, C-terminal domain |
| Family | IPR050187 | Lipid Phosphate Formation and Regulation |
| Homologous_superfamily | IPR016064 | NAD kinase/diacylglycerol kinase-like domain superfamily |
| Homologous_superfamily | IPR017438 | Inorganic polyphosphate/ATP-NAD kinase, N-terminal |
Domain Details Per Protein
| Protein | Length | Diacylglycerol kinase, catalytic domain | Inorganic polyphosphate/ATP-NAD kinase, N-terminal | Lipid Phosphate Formation and Regulation | NAD kinase/diacylglycerol kinase-like domain superfamily | YegS/DAGK, C-terminal domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PK50
|
869 |
Interactions and Pathways
No data available
Plasmids
No data available