ZFIN Image: Kinoshita et al., 2018, Fig. 4

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Figure Caption

Fig. 4

Expression of segmentation genes in the PSM is not fully suppressed in tbx6^+/−; ripply1^−/− mutants. Expression patterns of mesp-ba (A–C), mesp-bb (D–F), her1 (G–I), deltaC (J–L), tbx6 (M–O), pcdh8/papc (P–R), fgf8a (S–U), tbx18 (V–X), myod (Y–A′), and uncx4.1 (B′–D′) in sibling, tbx6^+/+; ripply1^−/−, and tbx6^+/−; ripply1^−/− embryos were examined by whole-mount in situ hybridization at the 18–22-somite stage. A line shows the ectopic expression of segmentation genes in the paraxial mesoderm. The arrowhead shows the polarized expression of somite polarity markers at the anterior PSM. Scale bar in D′ is 100 μm. All of the photos were taken at the same magnification. Higher magnification of the photos (S–D′) is shown in the Supplementary Fig. 7.

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Acknowledgments

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Reprinted from Mechanisms of Development, 152, Kinoshita, H., Ohgane, N., Fujino, Y., Yabe, T., Ovara, H., Yokota, D., Izuka, A., Kage, D., Yamasu, K., Takada, S., Kawamura, A., Functional roles of the Ripply-mediated suppression of segmentation gene expression at the anterior presomitic mesoderm in zebrafish, 21-31, Copyright (2018) with permission from Elsevier. Full text @ Mech. Dev.