ZFIN ID: ZDB-GENE-980526-242
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Gene Name: protocadherin 8
Gene Symbol: pcdh8    Nomenclature History

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Previous Names: papc (1), paraxial protocadherin (1), sb:eu375, zPAPC

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to localize to the integral component of plasma membrane. Is expressed in several structures, including germ ring; margin; mesoderm; presumptive mesoderm; and retina. Orthologous to human PCDH8 (protocadherin 8).
Genome Resources: Alliance (1),  Gene:30456 (1),  Ensembl(GRCz11):ENSDARG00000006467 (2)
GENE EXPRESSION
All Expression Data: 92 figures from 72 publications
Directly Submitted Expression Data: 7 figures (17 images) from Thisse et al., 2005 [eu375]
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21612 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pcdh8 N/A 1
    MO2-pcdh8 N/A 1
    MO3-pcdh8 N/A 1
    PHENOTYPE
    Data: Fig. 1 from Skouloudaki et al., 2009
    Observed in:
    DISEASE ASSOCIATED WITH pcdh8 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pcdh8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell adhesion (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR002126 Cadherin-like
    Domain IPR013164 Cadherin, N-terminal
    Homologous_superfamily IPR015919 Cadherin-like superfamily
    Conserved_site IPR020894 Cadherin conserved site
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS
    Addgene:pBS Zpapc
    CONSTRUCTS WITH SEQUENCES FROM pcdh8 No data available
    MARKER RELATIONSHIPS
    pcdh8 Contains: [SNP] rs3728249 (1), rs3728250 (1)
    pcdh8 Encodes: [EST] eu375 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131209 (1) 3137 bp
    Select Tool
    Genomic GenBank:CABZ01084081 (1) 42301 bp
    Select Tool
    Polypeptide UniProtKB:F1REQ8 (1) 950 aa
    Select Tool
    Sequence Clusters UniGene:75833 (1)
    Sequence Information (all 12)
    ORTHOLOGY for pcdh8 ( Chr: 9 )
    CITATIONS (141)