ZFIN ID: ZDB-GENE-020416-5
Gene Name: T-box transcription factor 6
Gene Symbol: tbx6    Nomenclature History

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Previous Names: tbx6r (1), fss (1), fused somites (1), id:ibd5070 (1), tbx24, z.TBX24 (1), ZF-TBX24 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of skeletal muscle tissue development; somatic motor neuron differentiation; and somitogenesis. Localizes to the chromatin. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Is expressed in mesoderm; presumptive mesoderm; slow muscle cell; tail bud; and trunk. Orthologous to human TBX6 (T-box transcription factor 6).
Genome Resources: Alliance (1),  Gene:192294 (1),  Ensembl(GRCz11):ENSDARG00000011785 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m774 Unknown Unknown Unknown SPONTANEOUS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17875 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38869 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41936 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tbx6_unspecified Unspecified Unknown Unknown
    te314a Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ti1 Small Deletion Unknown Frameshift, Premature Stop SPONTANEOUS
  • European Zebrafish Resource Center (EZRC) (order this)
  • y55 Unknown Unknown Unknown ENU
    y66 Unknown Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tbx6 N/A 7
    MO2-tbx6 N/A 1
    DISEASE ASSOCIATED WITH tbx6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spondylocostal dysostosis Alliance Spondylocostal dysostosis 5 122600
    DISEASE ASSOCIATED WITH tbx6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of skeletal muscle tissue development (more)
    Cellular Component chromatin (more)
    Molecular Function protein binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001699 Transcription factor, T-box
    Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
    Conserved_site IPR018186 Transcription factor, T-box, conserved site
    Homologous_superfamily IPR036960 T-box superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbx6-201 (1)    Ensembl 3049
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-tbx6 monoclonal IgG1 Mouse IHC 1
    Ab1-tbx6 polyclonal Rabbit IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbx6
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:tbx6-6xMYC) hsp70l tbx6 Danio rerio 1 3
    Tg(hsp70l:tbx6-mCherry) hsp70l mCherrytbx6 Danio rerio 1 2
    TgBAC(tbx6:GAL4FF) tbx6 GAL4FF Danio rerio 1 1
    MARKER RELATIONSHIPS
    tbx6 Contained in: [BAC] CH211-136M16 (1)
    tbx6 Encodes: [EST] eu421 (1), ibd5070 (1)
    [cDNA] MGC:194603 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_153666 (1) 3068 bp
    Genomic GenBank:AL929495 (1) 157568 bp
    Select Tool
    Polypeptide UniProtKB:Q8JIS6 (1) 874 aa
    Sequence Clusters UniGene:83300 (1)
    Sequence Information (all 18)
    ORTHOLOGY for tbx6 ( Chr: 12 )
    CITATIONS (149)