Gene

tbx6

ID
ZDB-GENE-020416-5
Name
T-box transcription factor 6
Symbol
tbx6 Nomenclature History
Previous Names
  • tbx6r (1)
  • fss (1)
  • fused somites (1)
  • id:ibd5070 (1)
  • tbx24
  • z.TBX24 (1)
  • ZF-TBX24 (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification; heart looping; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including regulation of skeletal muscle tissue development; somatic motor neuron differentiation; and somitogenesis. Located in chromatin. Is expressed in several structures, including margin; mesoderm; presumptive mesoderm; tail bud; and trunk. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human TBX6 (T-box transcription factor 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
67 figures from 38 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
36 figures from 17 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbx6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondylocostal dysostosis Alliance Spondylocostal dysostosis 5 122600
Associated With tbx6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Family IPR001699 Transcription factor, T-box
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR036960 T-box superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding T-box superfamily Transcription factor, T-box Transcription factor, T-box, conserved site
UniProtKB:Q8JIS6 874
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-tbx6 monoclonal IgG1 Mouse
  • IHC
1
Ab1-tbx6 polyclonal Rabbit
  • IHC
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations