Gene

ddx4

ID

ZDB-GENE-990415-272

Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

Symbol

ddx4 Nomenclature History

Previous Names

vas
vasa
vlg
wu:fi24g05
zgc:109812
zgc:158535

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have RNA binding activity and RNA helicase activity. Involved in germ cell development; gonad development; and regulation of meiotic cell cycle. Localizes to P granule. Is expressed in several structures, including blastodisc; germ line cell; reproductive system; shield; and unfertilized egg. Orthologous to human DDX4 (DEAD-box helicase 4).

Genome Resources

Note

None

Expression

All Expression Data

147 figures from 80 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Hartung et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ddx4 Human Ortholog

No data available

Associated With ddx4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site
Domain	IPR001650	Helicase, C-terminal
Domain	IPR011545	DEAD/DEAH box helicase domain
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR014014	RNA helicase, DEAD-box type, Q motif
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	ATP-dependent RNA helicase DEAD-box, conserved site	DEAD/DEAH box helicase domain	Helicase, C-terminal	Helicase superfamily 1/2, ATP-binding domain	P-loop containing nucleoside triphosphate hydrolase	RNA helicase, DEAD-box type, Q motif
UniProtKB:F8W3U8 InterPro	699
UniProtKB:Q8QFU0 InterPro	715
UniProtKB:O42107 InterPro	716
UniProtKB:F1QSP5 InterPro	688
UniProtKB:Q8QGG8 InterPro	715
UniProtKB:F1R6M3 InterPro	700
UniProtKB:F8W4P0 InterPro	687
UniProtKB:Q504J0 InterPro	306
UniProtKB:E7EZA2 InterPro	716
UniProtKB:O42378 InterPro	700
UniProtKB:A1L1Z2 InterPro	688

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	ddx4-204 (1) Ensembl	2787 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ddx4-205 (1) Ensembl	2519 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ddx4-206 (1) Ensembl	2856 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-ddx4		ddx4		Rabbit	IHC		19
Ab2-ddx4	polyclonal	ddx4		Rabbit	IHC WB		5

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations