Gene

wt1a

ID

ZDB-GENE-980526-558

Name

WT1 transcription factor a

Symbol

wt1a Nomenclature History

Previous Names

wt1
zwt1

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of apoptotic process; negative regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development. Predicted to be located in cytoplasm and nuclear speck. Is expressed in several structures, including cardiovascular system; gonad primordium; mesoderm; pleuroperitoneal region; and podocyte. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

104 figures from 65 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu357 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wt1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Denys-Drash syndrome	Alliance	Denys-Drash syndrome	194080
Frasier syndrome	Alliance	Frasier syndrome	136680
malignant mesothelioma	Alliance	Mesothelioma, somatic	156240
nephroblastoma	Alliance	Wilms tumor, type 1	194070
nephrotic syndrome type 4	Alliance	Nephrotic syndrome, type 4	256370
		Meacham syndrome	608978

Associated With wt1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000976	Wilm's tumour protein, N-terminal
Domain	IPR013087	Zinc finger C2H2-type
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Length	Wilm's tumour protein, N-terminal	Zinc finger C2H2 superfamily	Zinc finger C2H2-type
UniProtKB:Q9PUT7 InterPro	419

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	wt1a-201 (1) Ensembl	1874 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab4-wt1	polyclonal	wt1a		Rabbit	IHC		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations