Gene

wt1a

ID

ZDB-GENE-980526-558

Name

WT1 transcription factor a

Symbol

wt1a Nomenclature History

Previous Names

wt1
zwt1

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including kidney development; regulation of blood-brain barrier permeability; and visceral serous pericardium development. Predicted to be located in cytoplasm and nuclear speck. Is expressed in several structures, including cardiovascular system; central nervous system; mesoderm; renal system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma (multiple); and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

111 figures from 69 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu357 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 9 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wt1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Denys-Drash syndrome	Alliance	Denys-Drash syndrome	194080
Frasier syndrome	Alliance	Frasier syndrome	136680
malignant mesothelioma	Alliance	Mesothelioma, somatic	156240
nephroblastoma	Alliance	Wilms tumor, type 1	194070
nephrotic syndrome type 4	Alliance	Nephrotic syndrome, type 4	256370
		Meacham syndrome	608978

Associated With wt1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000976	Wilm's tumour protein, N-terminal
Domain	IPR013087	Zinc finger C2H2-type
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q9PUT7	InterPro	419
UniProtKB:A0AB32TC13	InterPro	416
UniProtKB:A0AB32TC36	InterPro	418
UniProtKB:A0AB32TEZ4	InterPro	415
UniProtKB:A0AB32THJ0	InterPro	381