Gene
wt1a
- ID
- ZDB-GENE-980526-558
- Name
- WT1 transcription factor a
- Symbol
- wt1a Nomenclature History
- Previous Names
-
- wt1
- zwt1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of apoptotic process; negative regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development. Predicted to be located in cytoplasm and nuclear speck. Is expressed in several structures, including cardiovascular system; gonad primordium; mesoderm; pleuroperitoneal region; and podocyte. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 104 figures from 65 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu357 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Denys-Drash syndrome | Alliance | Denys-Drash syndrome | 194080 |
Frasier syndrome | Alliance | Frasier syndrome | 136680 |
malignant mesothelioma | Alliance | Mesothelioma, somatic | 156240 |
nephroblastoma | Alliance | Wilms tumor, type 1 | 194070 |
nephrotic syndrome type 4 | Alliance | Nephrotic syndrome, type 4 | 256370 |
Meacham syndrome | 608978 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Wilm's tumour protein, N-terminal | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
---|---|---|---|---|
UniProtKB:Q9PUT7
|
419 |
Interactions and Pathways
No data available
Plasmids
No data available