Gene
sox19b
- ID
- ZDB-GENE-010111-1
- Name
- SRY-box transcription factor 19b
- Symbol
- sox19b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Contributes to DNA-binding transcription factor activity. Involved in neural crest cell differentiation and neural tube development. Acts upstream of or within several processes, including dorsal/ventral axis specification; epiboly involved in gastrulation with mouth forming second; and positive regulation of DNA-binding transcription factor activity. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; neural keel; neural rod; neural tube; and presumptive structure. Orthologous to human SOX15 (SRY-box transcription factor 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb174 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb426 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb883Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| m1434 | Allele with one deletion | Exon 1 | Unknown | TALEN | |
| ya3325 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| zf3268 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | SRY-related HMG-box transcription factor-like | Transcription factor SOX |
|---|---|---|---|---|---|---|
| UniProtKB:Q9DDD7 | InterPro | 292 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sox19b-201
(1)
|
Ensembl | 2,561 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-3K24 | ZFIN Curated Data | |
| Encodes | EST | cb174 | Thisse et al., 2001 | |
| Encodes | EST | fb76c08 | ||
| Encodes | EST | fe16f11 | ||
| Encodes | EST | fe24f11 | ||
| Encodes | EST | ibd3529 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63822 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131702 (1) | 2556 nt | ||
| Genomic | GenBank:CR848737 (2) | 158396 nt | ||
| Polypeptide | UniProtKB:Q9DDD7 (1) | 292 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- England, S.J., Campbell, P.C., Banerjee, S., Bates, R.L., Grieb, G., Fancher, W.F., Lewis, K.E. (2024) Transcriptional regulators with broad expression in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(11):1036-1055
- Riesle, A.J., Gao, M., Rosenblatt, M., Hermes, J., Hass, H., Gebhard, A., Veil, M., Grüning, B., Timmer, J., Onichtchouk, D. (2023) Activator-blocker model of transcriptional regulation by pioneer-like factors. Nature communications. 14:56775677
- Silva, N., Campinho, M.A. (2023) In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity. Frontiers in endocrinology. 14:11576851157685
- Wang, X., Zhu, J., Wang, H., Deng, W., Jiao, S., Wang, Y., He, M., Zhang, F., Liu, T., Hao, Y., Ye, D., Sun, Y. (2023) Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Nature communications. 14:79187918
- Gao, M., Veil, M., Rosenblatt, M., Riesle, A.J., Gebhard, A., Hass, H., Buryanova, L., Yampolsky, L.Y., Grüning, B., Ulianov, S.V., Timmer, J., Onichtchouk, D. (2022) Pluripotency factors determine gene expression repertoire at zygotic genome activation. Nature communications. 13:788
- Miao, L., Tang, Y., Bonneau, A.R., Chan, S.H., Kojima, M.L., Pownall, M.E., Vejnar, C.E., Gao, F., Krishnaswamy, S., Hendry, C.E., Giraldez, A.J. (2022) The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation. Molecular Cell. 82(5):986-1002.e9
- Michel, L., Palma, K., Cerda, M., Lagadec, R., Mayeur, H., Fuentès, M., Besseau, L., Martin, P., Magnanou, E., Blader, P., Concha, M.L., Mazan, S. (2022) Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel. Frontiers in cell and developmental biology. 10:1015074
- Okada, K., Aoki, K., Tabei, T., Sugio, K., Imai, K., Bonkohara, Y., Kamachi, Y. (2022) Key sequence features of CRISPR RNA for dual-guide CRISPR-Cas9 ribonucleoprotein complexes assembled with wild-type or HiFi Cas9. Nucleic acids research. 50(5):2854-2871
- Sato, K., Sakai, M., Ishii, A., Maehata, K., Takada, Y., Yasuda, K., Kotani, T. (2022) Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties. iScience. 25:104344
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