Gene

en1a

ID

ZDB-GENE-980526-216

Name

engrailed homeobox 1a

Symbol

en1a Nomenclature History

Previous Names

en-1
en1
eng1 (1)
eng1a
zgc:100771

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have sequence-specific DNA binding activity. Involved in axonogenesis involved in innervation. Predicted to localize to RSC-type complex. Human ortholog(s) of this gene implicated in Parkinson's disease. Is expressed in several structures, including adaxial cell; midbrain hindbrain boundary neural rod; musculature system; pectoral fin bud; and somite. Orthologous to human EN1 (engrailed homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

41 figures from 25 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7138684 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With en1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?ENDOVE syndrome, limb-brain type	619218

Associated With en1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Conserved_site	IPR019737	Homeobox engrailed-type, conserved site
Domain	IPR000747	Homeodomain engrailed
Domain	IPR001356	Homeodomain
Domain	IPR019549	Homeobox engrailed, C-terminal
Domain	IPR020479	Homeodomain, metazoa
Family	IPR050720	Engrailed Homeobox Transcription Factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily

Domain Details Per Protein

Protein	Length	Engrailed Homeobox Transcription Factors	Helix-turn-helix motif	Homedomain-like superfamily	Homeobox, conserved site	Homeobox engrailed, C-terminal	Homeobox engrailed-type, conserved site	Homeodomain	Homeodomain engrailed	Homeodomain, metazoa
UniProtKB:Q04896 InterPro	231
UniProtKB:Q68EL7 InterPro	231

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	en1a-201 (1) Ensembl	Ensembl		4,451 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-eng	monoclonal	en1a en1b en2a en2b	IgG1 , k	Mouse	IHC	Developmental Studies Hybridoma Bank	119

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations