Gene
en1a
- ID
- ZDB-GENE-980526-216
- Name
- engrailed homeobox 1a
- Symbol
- en1a Nomenclature History
- Previous Names
-
- en-1
- en1
- eng1 (1)
- eng1a
- zgc:100771
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in axonogenesis involved in innervation. Predicted to localize to nucleus. Is expressed in several structures, including adaxial cell; midbrain hindbrain boundary neural rod; musculature system; pectoral fin bud; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138684 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?ENDOVE syndrome, limb-brain type | 619218 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Helix-turn-helix motif | Homeobox, conserved site | Homeobox engrailed, C-terminal | Homeobox engrailed-type, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:Q04896
|
231 | ||||
|
UniProtKB:Q68EL7
|
231 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available