Gene
en1b
- ID
- ZDB-GENE-980526-6
- Name
- engrailed homeobox 1b
- Symbol
- en1b Nomenclature History
- Previous Names
-
- eng1b
- eng4
- engrailed 4
- wu:fc84e11
- zgc:113499
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within axonogenesis involved in innervation and neuron fate commitment. Predicted to be active in nucleus. Is expressed in midbrain hindbrain boundary neural keel; myoseptum; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138514 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?ENDOVE syndrome, limb-brain type | 619218 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Conserved_site | IPR019737 | Homeobox engrailed-type, conserved site |
| Domain | IPR000747 | Homeodomain engrailed |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR019549 | Homeobox engrailed, C-terminal |
| Domain | IPR020479 | Homeodomain, metazoa |
| Family | IPR050720 | Engrailed Homeobox Transcription Factors |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Engrailed Homeobox Transcription Factors | Homedomain-like superfamily | Homeobox, conserved site | Homeobox engrailed, C-terminal | Homeobox engrailed-type, conserved site | Homeodomain | Homeodomain engrailed | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B3Y5 | InterPro | 278 | ||||||||
| UniProtKB:Q5BJ08 | InterPro | 274 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available