Gene

en1b

ID

ZDB-GENE-980526-6

Name

engrailed homeobox 1b

Symbol

en1b Nomenclature History

Previous Names

eng1b
eng4
engrailed 4
wu:fc84e11
zgc:113499

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have sequence-specific DNA binding activity. Involved in axonogenesis involved in innervation and neuron fate commitment. Predicted to localize to RSC-type complex. Human ortholog(s) of this gene implicated in Parkinson's disease. Is expressed in myoseptum; nervous system; neural tube; and somite. Orthologous to human EN1 (engrailed homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

27 figures from 14 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7138514 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With en1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?ENDOVE syndrome, limb-brain type	619218

Associated With en1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Conserved_site	IPR019737	Homeobox engrailed-type, conserved site
Domain	IPR000747	Homeodomain engrailed
Domain	IPR001356	Homeodomain
Domain	IPR019549	Homeobox engrailed, C-terminal
Domain	IPR020479	Homeodomain, metazoa
Family	IPR050720	Engrailed Homeobox Transcription Factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily