Gene

en1b

ID
ZDB-GENE-980526-6
Name
engrailed homeobox 1b
Symbol
en1b Nomenclature History
Previous Names
  • eng1b
  • eng4
  • engrailed 4
  • wu:fc84e11
  • zgc:113499
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within axonogenesis involved in innervation and neuron fate commitment. Predicted to be active in nucleus. Is expressed in myoseptum; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
25 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With en1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?ENDOVE syndrome, limb-brain type 619218
Associated With en1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Conserved_site IPR019737 Homeobox engrailed-type, conserved site
Domain IPR000747 Homeobox domain engrailed
Domain IPR001356 Homeobox domain
Domain IPR019549 Homeobox engrailed, C-terminal
Domain IPR020479 Homeobox domain, metazoa
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox domain engrailed Homeobox domain, metazoa Homeobox engrailed, C-terminal Homeobox engrailed-type, conserved site Homeobox-like domain superfamily
UniProtKB:Q5BJ08 274
UniProtKB:Q9YGU2 259
UniProtKB:A0A0R4IKF8 168
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-eng monoclonal IgG1 , k Mouse
  • IHC
Developmental Studies Hybridoma Bank
118
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations