Gene

en2b

ID
ZDB-GENE-980526-40
Name
engrailed homeobox 2b
Symbol
en2b Nomenclature History
Previous Names
  • en3 (1)
  • eng2b
  • eng3 (1)
  • engrailed 3
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification; midbrain development; and midbrain-hindbrain boundary development. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; mandibular muscle; midbrain hindbrain boundary neural plate; midbrain hindbrain boundary neural rod; and neural keel. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
40 figures from 24 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With en2b Human Ortholog
No data available
Associated With en2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Conserved_site IPR019737 Homeobox engrailed-type, conserved site
Domain IPR000747 Homeobox domain engrailed
Domain IPR001356 Homeobox domain
Domain IPR019549 Homeobox engrailed, C-terminal
Domain IPR020479 Homeobox domain, metazoa
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Helix-turn-helix motif Homeobox, conserved site Homeobox domain Homeobox domain engrailed Homeobox domain, metazoa Homeobox engrailed, C-terminal Homeobox engrailed-type, conserved site Homeobox-like domain superfamily
UniProtKB:A3KPY2 261
UniProtKB:Q6IQW3 261
UniProtKB:P31533 261
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-eng monoclonal IgG1 , k Mouse
  • IHC
Developmental Studies Hybridoma Bank
114
Ab2-eng polyclonal Rabbit
  • IHC
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations