Gene

en2b

ID

ZDB-GENE-980526-40

Name

engrailed homeobox 2b

Symbol

en2b Nomenclature History

Previous Names

en3 (1)
eng2b
eng3 (1)
engrailed 3

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have sequence-specific DNA binding activity. Involved in cell fate specification; midbrain development; and midbrain-hindbrain boundary development. Predicted to localize to RSC-type complex. Human ortholog(s) of this gene implicated in autistic disorder. Is expressed in several structures, including central nervous system; mandibular muscle; midbrain hindbrain boundary neural plate; midbrain hindbrain boundary neural rod; and neural keel. Orthologous to human EN2 (engrailed homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

43 figures from 26 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7141696 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With en2b Human Ortholog

No data available

Associated With en2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Conserved_site	IPR019737	Homeobox engrailed-type, conserved site
Domain	IPR000747	Homeodomain engrailed
Domain	IPR001356	Homeodomain
Domain	IPR019549	Homeobox engrailed, C-terminal
Domain	IPR020479	Homeodomain, metazoa
Family	IPR050720	Engrailed Homeobox Transcription Factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily