PUBLICATION
A zebrafish engrailed-like homeobox sequence expressed during embryogenesis
- Authors
- Fjose, A., Eiken, H.G., Njolstad, P.R., Molven, A., and Hordvik, I.
- ID
- ZDB-PUB-961014-308
- Date
- 1988
- Source
- FEBS letters 231: 355-360 (Journal)
- Registered Authors
- Fjose, Anders, Molven, Anders
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Cyprinidae/genetics*
- DNA, Recombinant
- Drosophila melanogaster/genetics
- Embryonic and Fetal Development
- Gene Expression Regulation
- Genes, Homeobox*
- Molecular Sequence Data
- Nucleic Acid Hybridization
- Sequence Homology, Nucleic Acid
- Zebrafish/embryology
- Zebrafish/genetics*
- PubMed
- 2896133 Full text @ FEBS Lett.
Citation
Fjose, A., Eiken, H.G., Njolstad, P.R., Molven, A., and Hordvik, I. (1988) A zebrafish engrailed-like homeobox sequence expressed during embryogenesis. FEBS letters. 231:355-360.
Abstract
The zebrafish genome was found to contain two sequences which cross-hybridize strongly with the engrailed gene of Drosophila. Several independent clones containing one of these cross-hybridizing sequences were isolated from a zebrafish genomic library. Characterization of this region (ZF-EN) by DNA sequencing showed that it shares about 70% sequence identity with the engrailed homeobox. More extensive homeobox homology (greater than 90%) was found relative to the murine En genes. The closest relationship exists between ZF-EN and En-2 where the C-terminal domains (104 amino acids) encoded by these genes are almost identical. We also observed that ZF-EN and En-2 are very similar with respect to their transcript sizes and temporal expression patterns.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping