Gene
isl2a
- ID
- ZDB-GENE-980526-562
- Name
- ISL LIM homeobox 2a
- Symbol
- isl2a Nomenclature History
- Previous Names
-
- isl2
- zfIsl-2
- wu:fc29g02
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within blood vessel morphogenesis; exocrine pancreas development; and neuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; gut; liver and biliary system; nervous system; and neural tube. Orthologous to human ISL2 (ISL LIM homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 91 figures from 60 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu308 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR001781 | Zinc finger, LIM-type |
| Domain | IPR047244 | Insulin gene enhancer protein ISL-1/2-like, LIM domain1 |
| Family | IPR047169 | Insulin gene enhancer protein ISL-1/2-like |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Insulin gene enhancer protein ISL-1/2-like | Insulin gene enhancer protein ISL-1/2-like, LIM domain1 | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BA75 | InterPro | 360 | ||||||
| UniProtKB:A0A8M9PML2 | InterPro | 257 | ||||||
| UniProtKB:A0A8M9PGP9 | InterPro | 337 | ||||||
| UniProtKB:B3DH43 | InterPro | 359 | ||||||
| UniProtKB:P53406 | InterPro | 359 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-isl | monoclonal | IgG1 | Mouse |
|
Developmental Studies Hybridoma Bank
|
27 | |
| Ab2-isl | monoclonal | IgG2b | Mouse |
|
Developmental Studies Hybridoma Bank
|
144 |
Plasmids
No data available