Gene

isl2a

ID
ZDB-GENE-980526-562
Name
ISL LIM homeobox 2a
Symbol
isl2a Nomenclature History
Previous Names
  • isl2
  • zfIsl-2
  • wu:fc29g02
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in blood vessel morphogenesis; exocrine pancreas development; and neuron differentiation. Predicted to localize to nucleus. Is expressed in several structures, including ectoderm; gut; liver and biliary system; nervous system; and neural tube. Orthologous to human ISL2 (ISL LIM homeobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
90 figures from 60 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With isl2a Human Ortholog
No data available
Associated With isl2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR001781 Zinc finger, LIM-type
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Zinc finger, LIM-type
UniProtKB:B3DH43 359
UniProtKB:P53406 359
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-isl monoclonal IgG1 Mouse
  • IHC
Developmental Studies Hybridoma Bank
25
Ab2-isl monoclonal IgG2b Mouse
  • IHC
Developmental Studies Hybridoma Bank
122
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations