Gene
hdac1
- ID
- ZDB-GENE-020419-32
- Name
- histone deacetylase 1
- Symbol
- hdac1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on secondary heart field specification. Acts upstream of or within several processes, including cardiac muscle cell proliferation; digestive system development; and nervous system development. Predicted to be located in nucleus. Predicted to be part of NuRD complex. Is expressed in immature eye; nervous system; pectoral fin; and pharyngeal arch. Orthologous to human HDAC1 (histone deacetylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101582 (9 images)
- IMAGE:6904025 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 69 figures from 24 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b382 | Allele with one point mutation | Intron 4 | Cryptic Acceptor Splice Site | ENU | |
| hi1618Tg | Transgenic insertion | Exon 1 | Unknown | DNA | |
| hi2628Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| is70 | Allele with one deletion | Exon 5 | Frameshift | CRISPR | |
| la013452Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nl18 | Allele with one point mutation | Donor Splice Site of Exon 7 | Unknown | ENU | |
| rw399 | Allele with one point mutation | Unknown | Unknown | not specified | |
| s436 | Allele with one point mutation | Unknown | Missense | not specified | |
| sa3005 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| t22925 | Allele with one point mutation | Unknown | Unknown | not specified |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hdac1 | (2) | |
| CRISPR2-hdac1 | (2) | |
| CRISPR3-hdac1 | Bu et al., 2021 | |
| MO1-hdac1 | N/A | (22) |
| MO2-hdac1 | N/A | Harrison et al., 2011 |
| MO3-hdac1 | N/A | Huang et al., 2013 |
| MO4-hdac1 | N/A | Huang et al., 2013 |
| MO5-hdac1 | N/A | (3) |
| MO6-hdac1 | N/A | Bühler et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Histone deacetylase | Histone deacetylase and polyamine deacetylase | Histone deacetylase domain | Histone deacetylase domain superfamily | Histone deacetylase family | Ureohydrolase domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8JIY7
|
480 | ||||||
|
UniProtKB:A0A2R8QIW0
|
484 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(her4.3:TETA,TETRE:YFP-dnhdac1) |
| 1 | Cavone et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-130A3 | ZFIN Curated Data | |
| Encodes | EST | fb19h11 | ZFIN Curated Data | |
| Encodes | EST | fi06f03 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6904025 | Thisse et al., 2004 | |
| Encodes | EST | zf637-2-001987 | ||
| Encodes | STS | chunp6919 | ||
| Encodes | cDNA | MGC:65818 | ||
| Encodes | cDNA | MGC:101582 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193070 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173236 (1) | 2213 nt | ||
| Genomic | GenBank:CU633192 (2) | 93120 nt | ||
| Polypeptide | UniProtKB:A0A2R8QIW0 (1) | 484 aa |
- Angom, R.S., Joshi, A., Patowary, A., Sivadas, A., Ramasamy, S., K V, S., Kaushik, K., Sabharwal, A., Lalwani, M.K., K, S., Singh, N., Scaria, V., Sivasubbu, S. (2024) Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function. Frontiers in cell and developmental biology. 12:13392921339292
- Faillace, M.P., Ortiz, J., Rocco, L., Bernabeu, R. (2024) Histone Methyltransferase G9a Plays an Essential Role on Nicotine Preference in Zebrafish. Molecular neurobiology. 61(9):6245-6263
- Zhao, S., Mo, G., Wang, Q., Xu, J., Yu, S., Huang, Z., Liu, W., Zhang, W. (2024) Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b. Cell death discovery. 10:182182
- Zhao, S., Wang, C., Luo, H., Li, F., Wang, Q., Xu, J., Huang, Z., Liu, W., Zhang, W. (2024) A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family. Journal of genetics and genomics = Yi chuan xue bao. 51(9):900-910
- Boos, A., Gahr, B.M., Park, D.D., Braun, V., Bühler, A., Rottbauer, W., Just, S. (2023) Hdac1-deficiency affects the cell cycle axis Cdc25-Cdk1 causing impaired G2/M phase progression and reduced cardiomyocyte proliferation in zebrafish. Biochemical and Biophysical Research Communications. 665:9810698-106
- DeMoya, R.A., Forman-Rubinsky, R.E., Fontaine, D., Shin, J., Watkins, S.C., Lo, C.W., Tsang, M. (2023) Sin3a associated protein 130 kDa, sap130, plays an evolutionary conserved role in zebrafish heart development. Frontiers in cell and developmental biology. 11:11971091197109
- Jones, A.A., Willoner, T., Mishoe Hernandez, L., DeLaurier, A. (2023) Exposure to valproic acid (VPA) reproduces hdac1 loss of function phenotypes in zebrafish. microPublication. Biology. 2023:
- Volpatti, J.R., Ghahramani-Seno, M.M., Mansat, M., Sabha, N., Sarikaya, E., Goodman, S.J., Chater-Diehl, E., Celik, A., Pannia, E., Froment, C., Combes-Soia, L., Maani, N., Yuki, K.E., Chicanne, G., Uusküla-Reimand, L., Monis, S., Alvi, S.A., Genetti, C.A., Payrastre, B., Beggs, A.H., Bonnemann, C.G., Muntoni, F., Wilson, M.D., Weksberg, R., Viaud, J., Dowling, J.J. (2022) X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition. Acta Neuropathologica. 144(3):537-563
- Bu, H., Ding, Y., Li, J., Zhu, P., Shih, Y.H., Wang, M., Zhang, Y., Lin, X., Xu, X. (2021) Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish. JCI insight. 6(24):
- Bühler, A., Gahr, B.M., Park, D.D., Bertozzi, A., Boos, A., Dalvoy, M., Pott, A., Oswald, F., Kovall, R.A., Kühn, B., Weidinger, G., Rottbauer, W., Just, S. (2021) Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish. PLoS Genetics. 17:e1009890
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