Gene
pbx4
- ID
- ZDB-GENE-000201-18
- Name
- pre-B-cell leukemia transcription factor 4
- Symbol
- pbx4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables DNA binding activity and DNA-binding transcription factor activity. Involved in nervous system development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; heart development; and nervous system development. Located in nucleus. Orthologous to human PBX4 (PBX homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7152524 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 34 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b557 | Allele with one point mutation | Unknown | Premature Stop | not specified | |
| hi933Tg | Transgenic insertion | Intron 2 | Unknown | DNA | |
| hi1126Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028943Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028944Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| scm14 | Allele with one point mutation | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pbx4 | Farr et al., 2018 | |
| CRISPR2-pbx4 | Farr et al., 2018 | |
| CRISPR3-pbx4 | Farr et al., 2018 | |
| MO1-pbx4 | N/A | (2) |
| MO2-pbx4 | N/A | (13) |
| MO3-pbx4 | N/A | (11) |
| MO4-pbx4 | N/A | Teoh et al., 2010 |
| MO5-pbx4 | N/A | Teoh et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | KN homeodomain | PBX, PBC domain | Three Amino acid Loop Extension (TALE) homeobox |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PW77 | InterPro | 343 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-189E16 | ZFIN Curated Data | |
| Encodes | EST | fb77e11 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7152524 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:193543 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193573 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131447 (1) | 2854 nt | ||
| Genomic | GenBank:CU302192 (1) | 159807 nt | ||
| Polypeptide | UniProtKB:Q9PW77 (1) | 343 aa |
- Holowiecki, A., Linstrum, K., Ravisankar, P., Chetal, K., Salomonis, N., Waxman, J.S. (2020) Pbx4 limits heart size and fosters arch artery formation through partitioning second heart field progenitors and restricting proliferation. Development (Cambridge, England). 147(5):
- Itoh, T., Takeuchi, M., Sakagami, M., Asakawa, K., Sumiyama, K., Kawakami, K., Shimizu, T., Hibi, M. (2020) Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish. Development (Cambridge, England). 147(19):
- Stanney, W., Ladam, F., Donaldson, I.J., Parsons, T.J., Maehr, R., Bobola, N., Sagerström, C.G. (2019) Combinatorial action of NF-Y and TALE at embryonic enhancers defines distinct gene expression programs during zygotic genome activation in zebrafish. Developmental Biology. 459(2):161-180
- Farr, G.H., Imani, K., Pouv, D., Maves, L. (2018) Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects.. Disease models & mechanisms. 11(10):
- Ladam, F., Stanney, W., Donaldson, I.J., Yildiz, O., Bobola, N., Sagerström, C.G. (2018) TALE factors use two distinct functional modes to control an essential zebrafish gene expression program. eLIFE. 7
- Selland, L.G., Koch, S., Laraque, M., Waskiewicz, A.J. (2018) Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development. Mechanisms of Development. 150:28-41
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kao, R.M., Rurik, J.G., Farr, G.H., Dong, X.R., Majesky, M.W., Maves, L. (2015) Pbx4 is Required for the Temporal Onset of Zebrafish Myocardial Differentiation. Journal of developmental biology. 3:93-111
- Uribe, R.A., Bronner, M.E. (2015) Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development. Molecular biology of the cell. 26(21):3728-40
- Choe, S.K., Ladam, F., and Sagerström, C.G. (2014) TALE factors poise promoters for activation by Hox proteins. Developmental Cell. 28(2):203-211
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