Gene

pbx3b

ID

ZDB-GENE-000405-3

Name

pre-B-cell leukemia homeobox 3b

Symbol

pbx3b Nomenclature History

Previous Names

pbx3.1 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Predicted to localize to nuclear chromatin. Is expressed in brain; eye; and telencephalon. Orthologous to human PBX3 (PBX homeobox 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu552 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Farr et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pbx3b Human Ortholog

No data available

Associated With pbx3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR005542	PBX, PBC domain
Domain	IPR008422	KN homeodomain
Family	IPR050224	Three Amino acid Loop Extension (TALE) homeobox
Homologous_superfamily	IPR009057	Homedomain-like superfamily

Domain Details Per Protein

Protein	Length	Homedomain-like superfamily	Homeobox, conserved site	Homeodomain	KN homeodomain	PBX, PBC domain	Three Amino acid Loop Extension (TALE) homeobox
UniProtKB:A0A8M3BBW5 InterPro	388
UniProtKB:A0A8M3AVA6 InterPro	459
UniProtKB:A0A8M6Z257 InterPro	382
UniProtKB:Q9I9B5 InterPro	350
UniProtKB:A0A8M3B234 InterPro	461
UniProtKB:A4UU10 InterPro	386
UniProtKB:A0A8M3AVA3 InterPro	362
UniProtKB:B0V334 InterPro	376
UniProtKB:A0A8M3B506 InterPro	469
UniProtKB:A0A8M3AV99 InterPro	471

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pbx3b-201 (1) Ensembl	Ensembl	3237 nt	Select Tool ZFIN BLAST
mRNA	pbx3b-202 (1) Ensembl	Ensembl	3315 nt	Select Tool ZFIN BLAST
mRNA	pbx3b-203 (1) Ensembl	Havana	3032 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	pbx3b-204 (1) Ensembl	Havana	1354 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	pbx3b-210 (1) Ensembl	Havana	3319 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	pbx3b-211 (1) Ensembl	Ensembl	1524 nt	Select Tool ZFIN BLAST
ncRNA	pbx3b-002 (1) Ensembl	Havana	919 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	pbx3b-003 (1) Ensembl	Havana	713 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	pbx3b-004 (1) Ensembl	Havana	237 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	pbx3b-005 (1) Ensembl	Havana	431 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	pbx3b-006 (1) Ensembl	Havana	378 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-pbx	polyclonal	pbx1b pbx2 pbx3b pbx4		Rabbit	WB		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations