Gene
pbx3b
- ID
- ZDB-GENE-000405-3
- Name
- pre-B-cell leukemia homeobox 3b
- Symbol
- pbx3b Nomenclature History
- Previous Names
-
- pbx3.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in several processes, including embryonic organ development; eye development; and nervous system development. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in brain; eye; and telencephalon. Orthologous to human PBX3 (PBX homeobox 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu552 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Farr et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2431 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa8808 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41255 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41256 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| scm8 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pbx2,pbx3b | Farr et al., 2018 | |
| CRISPR2-pbx3b | Moreno-Campos et al., 2024 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | KN homeodomain | PBX, PBC domain | Three Amino acid Loop Extension (TALE) homeobox |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3BBW5 | InterPro | 388 | ||||||
| UniProtKB:A0A8M3AVA6 | InterPro | 459 | ||||||
| UniProtKB:A0A8M6Z257 | InterPro | 382 | ||||||
| UniProtKB:Q9I9B5 | InterPro | 350 | ||||||
| UniProtKB:A0A8M3B234 | InterPro | 461 | ||||||
| UniProtKB:A4UU10 | InterPro | 386 | ||||||
| UniProtKB:A0A8M3AVA3 | InterPro | 362 | ||||||
| UniProtKB:B0V334 | InterPro | 376 | ||||||
| UniProtKB:A0A8M3B506 | InterPro | 469 | ||||||
| UniProtKB:A0A8M3AV99 | InterPro | 471 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pbx3b-201
(1)
|
Ensembl | 3,237 nt | ||
| mRNA |
pbx3b-202
(1)
|
Ensembl | 3,315 nt | ||
| mRNA |
pbx3b-203
(1)
|
Ensembl | 3,032 nt | ||
| mRNA |
pbx3b-204
(1)
|
Ensembl | 1,354 nt | ||
| mRNA |
pbx3b-210
(1)
|
Ensembl | 3,319 nt | ||
| mRNA |
pbx3b-211
(1)
|
Ensembl | 1,524 nt | ||
| ncRNA |
pbx3b-002
(1)
|
Ensembl | 919 nt | ||
| ncRNA |
pbx3b-003
(1)
|
Ensembl | 713 nt | ||
| ncRNA |
pbx3b-004
(1)
|
Ensembl | 237 nt | ||
| ncRNA |
pbx3b-005
(1)
|
Ensembl | 431 nt | ||
| ncRNA |
pbx3b-006
(1)
|
Ensembl | 431 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-29N4 | ZFIN Curated Data | |
| Contained in | BAC | CH73-147N15 | ZFIN Curated Data | |
| Contained in | BAC | CH73-332L6 | ZFIN Curated Data | |
| Contained in | BAC | CH73-367H6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-284O11 | ZFIN Curated Data | |
| Encodes | EST | eu552 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193587 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098243 (1) | 3345 nt | ||
| Genomic | GenBank:CT737172 (1) | 169571 nt | ||
| Polypeptide | UniProtKB:A0A8M3AV99 (1) | 471 aa |
- Moreno-Campos, R., Singleton, E.W., Uribe, R.A. (2024) A targeted CRISPR-Cas9 mediated F0 screen identifies genes involved in establishment of the enteric nervous system. PLoS One. 19:e0303914e0303914
- Zuppo, D.A., Missinato, M.A., Santana-Santos, L., Li, G., Benos, P.V., Tsang, M. (2023) Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Development (Cambridge, England). 150(6):
- Baker, P.A., Ibarra-García-Padilla, R., Venkatesh, A., Singleton, E.W., Uribe, R.A. (2022) In Toto imaging of early enteric nervous system Development reveals that gut colonization is tied to proliferation downstream of ret. Development (Cambridge, England). 149(21)
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Howard, A.G., Baker, P.A., Ibarra-García-Padilla, R., Moore, J.A., Rivas, L.J., Tallman, J.J., Singleton, E.W., Westheimer, J.L., Corteguera, J.A., Uribe, R.A. (2021) An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution. eLIFE. 10:
- Wang, F., Ren, D., Liang, X., Ke, S., Zhang, B., Hu, B., Song, X., Wang, X. (2019) A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic acids research. 47(12):6315-6329
- Farr, G.H., Imani, K., Pouv, D., Maves, L. (2018) Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects.. Disease models & mechanisms. 11(10):
- Mullally, M., Albrecht, C., Horton, M., Laboissonniere, L.A., Goetz, J.J., Chowdhury, R., Manning, A., Wester, A.K., Bose, Q., Trimarchi, J.M. (2016) Expression Profiling of Developing Zebrafish Retinal Cells. Zebrafish. 13(4):272-80
- Freeman, J.L., Weber, G.J., Peterson, S.M., Nie, L.H. (2014) Embryonic ionizing radiation exposure results in expression alterations of genes associated with cardiovascular and neurological development, function, and disease and modified cardiovascular function in zebrafish. Frontiers in genetics. 5:268
- Armant, O., März, M., Schmidt, R., Ferg, M., Diotel, N., Ertzer, R., Bryne, J.C., Yang, L., Baader, I., Reischl, M., Legradi, J., Mikut, R., Stemple, D., Ijcken, W.V., van der Sloot, A., Lenhard, B., Strähle, U., and Rastegar, S. (2013) Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Developmental Biology. 380(2):351-62
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