ZFIN ID: ZDB-PUB-000927-4
lazarus is a novel pbx gene that globally mediates Hox gene function in zebrafish
Pöpperl, H., Rikhof, H., Chang, H., Haffter, P., Kimmel, C.B., and Moens, C.B.
Date: 2000
Source: Molecular Cell   6(2): 255-267 (Journal)
Registered Authors: Chang, H., Haffter, Pascal, Kimmel, Charles B., Moens, Cecilia, Rikhof, Holly
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning/genetics*
  • DNA-Binding Proteins/genetics
  • Embryo, Nonmammalian/physiology
  • Gene Expression Regulation*
  • Genes, Homeobox*
  • Genes, Regulator*
  • Mutagenesis
  • Polymerase Chain Reaction
  • Proto-Oncogene Proteins/genetics
  • Rhombencephalon/embryology*
  • Zebrafish/embryology*
  • Zebrafish/genetics*
PubMed: 10983974 Full text @ Mol. Cell
Individual vertebrate Hox genes specify aspects of segment identity along the anterior-posterior axis. The exquisite in vivo specificity of Hox proteins is thought to result from their interactions with members of the Pbx/Exd family of homeodomain proteins. Here, we report the identification and cloning of a zebrafish gene, lazarus, which is required globally for segmental patterning in the hindbrain and anterior trunk. We show that lazarus is a novel pbx gene and provide evidence that it is the primary pbx gene required for the functions of multiple hox genes during zebrafish development. lazarus plays a critical role in orchestrating the corresponding segmentation of the hindbrain and the pharyngeal arches, a key step in the development of the vertebrate body plan.