|ZFIN ID: ZDB-PUB-000927-4|
lazarus is a novel pbx gene that globally mediates Hox gene function in zebrafish
Pöpperl, H., Rikhof, H., Chang, H., Haffter, P., Kimmel, C.B., and Moens, C.B.
|Source:||Molecular Cell 6(2): 255-267 (Journal)|
|Registered Authors:||Chang, H., Haffter, Pascal, Kimmel, Charles B., Moens, Cecilia, Rikhof, Holly|
|PubMed:||10983974 Full text @ Mol. Cell|
Pöpperl, H., Rikhof, H., Chang, H., Haffter, P., Kimmel, C.B., and Moens, C.B. (2000) lazarus is a novel pbx gene that globally mediates Hox gene function in zebrafish. Molecular Cell. 6(2):255-267.
ABSTRACTIndividual vertebrate Hox genes specify aspects of segment identity along the anterior-posterior axis. The exquisite in vivo specificity of Hox proteins is thought to result from their interactions with members of the Pbx/Exd family of homeodomain proteins. Here, we report the identification and cloning of a zebrafish gene, lazarus, which is required globally for segmental patterning in the hindbrain and anterior trunk. We show that lazarus is a novel pbx gene and provide evidence that it is the primary pbx gene required for the functions of multiple hox genes during zebrafish development. lazarus plays a critical role in orchestrating the corresponding segmentation of the hindbrain and the pharyngeal arches, a key step in the development of the vertebrate body plan.