FIGURE

Figure 3

ID

ZDB-FIG-260505-78

Publication

Hoffmann et al., 2026 - Linking shox/shox2 deficiency with fgfr3 gain-of-function and natriuretic peptides

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Figure 3

Tissue-specific nCounter expression analysis of fgfr3 in zebrafish embryos 55 hpf upon shox(A), shox2(B) and shox/shox2(C) knockdown in fin (n=3), heart (n=4-5), head (n=4) and whole embryo (n=6). MO = morpholino. (D) Body length of zebrafish embryos 72 hpf after shox and shox2 knockdown and CNP treatment (10 µM), assessed in 10–15 whole embryos per condition (n=3). (E) nCounter expression analysis of fgfr3, nppa, nppb, nppc in zebrafish embryos 72 hpf after shox and shox2 knockdown and CNP treatment (10µM), assessed in 10–15 whole embryos per condition (n=2). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. MO = morpholino, hpf = hours post fertilization, n = number of independent experiments.

Expression Data

Genes:	fgfr3 nppa nppb nppc
Fish:	AB/TU AB/TU + MO3-shox AB/TU + MO3-shox2 f1Tg (AB/TU) f1Tg + MO3-shox (AB/TU) f1Tg + MO3-shox2 (AB/TU) f1Tg + MO3-shox + MO3-shox2 (AB/TU)
Condition:	chemical treatment by environment: C-Type natriuretic peptide
Knockdown Reagents:	MO3-shox MO3-shox2
Anatomical Terms:	head heart pectoral fin whole organism
Stage Range:	Long-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TU AB/TU + MO3-shox AB/TU + MO3-shox2 f1Tg + MO3-shox2 (AB/TU) f1Tg + MO3-shox + MO3-shox2 (AB/TU)
Condition:	chemical treatment by environment: C-Type natriuretic peptide
Knockdown Reagents:	MO3-shox MO3-shox2
Observed In:	pectoral fin whole organism
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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