FIGURE

Fig. 6

ID

ZDB-FIG-260403-29

Publication

Pérez-Escudero et al., 2026 - GPER1 reduces skin inflammation by inhibiting keratinocyte proliferation

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Fig. 6

Pharmacological activation of Gper1 attenuates keratinocyte hyperproliferation in Spint1a-deficient larvae.

a Schematic of the experimental procedure used. Spint1a-deficient embryos were treated with G-1 or vehicle (DMSO) at 1 dpf by bath immersion. At 2 dpf, images were taken to analyze neutrophil distribution and KC aggregates. Quantification of neutrophil distribution (b) and number of KC aggregates (c) in tail in every condition. d Representative merge (red and bright field) images of 3 dpf control and treated larvae, showing neutrophils and KC aggregates. Each dot represents one individual, and the means and SEM for each group are also shown. P values were calculated by Student’s t test (c, d, f) and by Pearson Correlation test (g). ns not significant; ***P ≤ 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	spint1a^{hi2217Tg/hi2217Tg}; nz50Tg/nz50Tg
Condition:	chemical treatment by environment: G-1
Observed In:	keratinocyte proliferation
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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