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Publication: Pérez-Escudero et al., 2026 - GPER1 reduces skin inflammation by inhibiting keratinocyte proliferation
All Figures: Figures for Pérez-Escudero et al., 2026

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Fig. 6 Pharmacological activation of Gper1 attenuates keratinocyte hyperproliferation in Spint1a-deficient larvae.

a Schematic of the experimental procedure used. Spint1a-deficient embryos were treated with G-1 or vehicle (DMSO) at 1 dpf by bath immersion. At 2 dpf, images were taken to analyze neutrophil distribution and KC aggregates. Quantification of neutrophil distribution (b) and number of KC aggregates (c) in tail in every condition. d Representative merge (red and bright field) images of 3 dpf control and treated larvae, showing neutrophils and KC aggregates. Each dot represents one individual, and the means and SEM for each group are also shown. P values were calculated by Student’s t test (c, d, f) and by Pearson Correlation test (g). ns not significant; ***P ≤ 0.001.

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