FIGURE

FIGURE 4

ID

ZDB-FIG-260105-66

Publication

Tseng et al., 2025 - Disruption of Swell1/VRAC function impairs initial hemodynamics and activates compensatory leukotriene signaling in zebrafish circulation development

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FIGURE 4

Inhibition of cardiac output by nifedipine further compromises hemodynamics in dKO embryos. (A) Nifedipine treatment significantly reduced the heart rate in WT embryos at 48 hpf and in dKO embryos at 48 and 72 hpf. (B) The vessel diameter of the dorsal aorta (DA) was significantly reduced in both WT and dKO embryos at 30 and 48 hpf following nifedipine treatment. The posterior cardinal vein (PCV) diameter was also significantly reduced in dKO embryos at 48 hpf. (C) Nifedipine treatment significantly reduced blood cell flow (hemodynamics) in both WT and dKO embryos at 30 and 48 hpf, but not at 72 hpf. The sample size (n) for each group is indicated above the scatter plot. The data were collected from two biological replicates. Nifedipine: vehicle control with 0.1% DMSO; +, 10 µM nifedipine. ns, no significance; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB lrrc8aa^{twu0421/twu0421}; lrrc8ab^{twu0422/twu0422} (AB)
Condition:	chemical treatment by environment: nifedipine
Observed In:	dorsal aorta dorsal aorta blood circulation heart contraction intersegmental vessel blood circulation posterior cardinal vein
Stage Range:	Prim-15 to Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol