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Figure 7

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ZDB-FIG-251125-15

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Toso et al., 2025 - Human and zebrafish mineralocorticoid receptors reporter cell assays to assess the activity of chemicals

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Figure 7

HMR and zfMR are targets of environmental chemicals

Dose-response curves of environmental chemicals in UG5LN-GAL4-hMR (A and B) and UG5LN-GAL4-zfMR (C and D) cells. Chemicals were tested in the presence of aldosterone 10⁻⁹ M in UG5LN-GAL4-hMR cells and 0.5 10⁻⁹ M in UG5LN-GAL4-zfMR cells (antagonism test). Results are expressed as the percentage of the maximum luciferase activity induced by 10⁻⁸ M aldosterone. The curves are presented as a non-linear regression; log (ligand) versus response. IC₅₀ values (10⁻⁶ M) are shown in Table 7.

Data are presented as means ± SD values. n (replicates per experiment) = 4 per group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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